Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition

doi:10.1016/j.carbpol.2021.118567

IOCAS-IR > 实验海洋生物学重点实验室

	Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition
	Wu, Ning 1,3,5; Li, Zhi1,2,4 ; Wang, Jing1,2 ; Geng, Lihua 1,2; Yue, Yang1,2 ; Deng, Zhenzhen 1,2,4; Wang, Qingchi1,2,4 ; Zhang, Quanbin 1,2,4
	2021-12-01
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
卷号	273 页码:10
通讯作者	Wu, Ning([email protected]) ; Zhang, Quanbin([email protected])
摘要	Diffuse alveolar injury and pulmonary fibrosis (PF) are the main causes of death of Covid-19 cases. In this study a low molecular weight fucoidan (LMWF) with unique structural was obtained from Laminaria japonica, and its antiPF and anti-epithelial-mesenchymal transition (EMT) bioactivity were investigated both in vivo and in vitro. After LWMF treatment the fibrosis and inflammatory factors stimulated by Bleomycin (BLM) were in lung tissue. Immunohistochemical and Western-blot results found the expression of COL2A1, beta-catenin, TGF-beta, TNF-alpha and IL-6 were declined in mice lung tissue. Besides, the phosphorylation of PI3K and Akt were inhibited by LMWF. In addition, the progression of EMT induced by TGF-beta 1 was inhibited by LMWF through down-regulated both TGF-beta/Smad and PI3K/AKT signaling pathways. These data indicate that unique LMWF can protect the lung from fibrosis by weakening the process of inflammation and EMT, and it is a promising therapeutic option for the treatment of PF.
关键词	Fucoidans COVID-19 Pulmonary fibrosis Epithelial-mesenchymal transition TGF-beta PI3K/AKT pathway
DOI	10.1016/j.carbpol.2021.118567
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2019YFD0900705]; Nantong Science and Technology program[MS12021037]; Special Open Fund of Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology[OF2020NO02]
WOS研究方向	Chemistry ; Polymer Science
WOS类目	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS记录号	WOS:000704364500005
出版者	ELSEVIER SCI LTD
引用统计	被引频次：29[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/176619
专题	实验海洋生物学重点实验室
通讯作者	Wu, Ning; Zhang, Quanbin
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Nantong Zhongke Marine Sci & Technol Res & Dev Ct, Nantong, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Wu, Ning,Li, Zhi,Wang, Jing,et al. Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition[J]. CARBOHYDRATE POLYMERS,2021,273:10.
APA	Wu, Ning.,Li, Zhi.,Wang, Jing.,Geng, Lihua.,Yue, Yang.,...&Zhang, Quanbin.(2021).Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition.CARBOHYDRATE POLYMERS,273,10.
MLA	Wu, Ning,et al."Low molecular weight fucoidan attenuating pulmonary fibrosis by relieving inflammatory reaction and progression of epithelial-mesenchymal transition".CARBOHYDRATE POLYMERS 273(2021):10.

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