Adenosine Triggers Larval Settlement and Metamorphosis in the Mussel Mytilopsis sallei through the ADK-AMPK-FoxO Pathway

doi:10.1021/acschembio.1c00175

	Adenosine Triggers Larval Settlement and Metamorphosis in the Mussel Mytilopsis sallei through the ADK-AMPK-FoxO Pathway
	He, Jian 1,2; Wu, Zhiwen 1; Chen, Liying 1; Dai, Qi 1; Hao, Huanhuan 1; Su, Pei 1; Ke, Caihuan 1,3; Feng, Danqing 1
	2021-08-20
发表期刊	ACS CHEMICAL BIOLOGY
ISSN	1554-8929
卷号	16 期号:8 页码:1390-1400
通讯作者	Feng, Danqing([email protected])
摘要	Settlement and metamorphosis of planktonic larvae into benthic adults are critical components of a diverse range of marine invertebrate-mediated processes such as the formation of mussel beds and coral reefs, the recruitment of marine shellfisheries, and the initiation of macrobiofouling. Although larval settlement and metamorphosis induced by natural chemical cues is widespread among marine invertebrates, the mechanisms of action remain poorly understood. Here, we identified that the molecular target of adenosine (an inducer of larval settlement and metamorphosis from conspecific adults in the invasive biofouling mussel Mytilopsis sallei) is adenosine kinase (ADK). The results of transcriptomic analyses, pharmacological assays, temporal and spatial gene expression analyses, and siRNA interference, suggest that ATP-dependent phosphorylation of adenosine catalyzed by ADK activates the downstream AMPK-FoxO signaling pathway, inducing larval settlement and metamorphosis in M. sallei. This study not only reveals the role of the ADK-AMPK-FoxO pathway in larval settlement and metamorphosis of marine invertebrates but it also deepens our understanding of the functions and evolution of adenosine signaling, a process that is widespread in biology and important in medicine.
DOI	10.1021/acschembio.1c00175
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2018YFC1407505]; National Natural Science Foundation of China[41276127]; Youth Innovation Fund Project of Xiamen[3502Z20206053]; Project of Key Laboratory of Marine Ecological Monitoring and Restoration Technology, Ministry of Nature Resources[2020ZX01]; Science and Technology Project of Fujian Province[2018Y0076]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000697396400011
出版者	AMER CHEMICAL SOC
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/176446
专题	海洋环境腐蚀与生物污损重点实验室
通讯作者	Feng, Danqing
作者单位	1.Xiamen Univ, Coll Ocean & Earth Sci, State Prov Joint Engn Lab Marine Bioprod & Techno, Xiamen 361102, Peoples R China 2.Chinese Acad Sci, Key Lab Marine Environm Corros & Biofouling, Inst Oceanol, Qingdao 266071, Peoples R China 3.Xiamen Univ, State Key Lab Marine Environm Sci, Xiamen 361102, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	He, Jian,Wu, Zhiwen,Chen, Liying,et al. Adenosine Triggers Larval Settlement and Metamorphosis in the Mussel Mytilopsis sallei through the ADK-AMPK-FoxO Pathway[J]. ACS CHEMICAL BIOLOGY,2021,16(8):1390-1400.
APA	He, Jian.,Wu, Zhiwen.,Chen, Liying.,Dai, Qi.,Hao, Huanhuan.,...&Feng, Danqing.(2021).Adenosine Triggers Larval Settlement and Metamorphosis in the Mussel Mytilopsis sallei through the ADK-AMPK-FoxO Pathway.ACS CHEMICAL BIOLOGY,16(8),1390-1400.
MLA	He, Jian,et al."Adenosine Triggers Larval Settlement and Metamorphosis in the Mussel Mytilopsis sallei through the ADK-AMPK-FoxO Pathway".ACS CHEMICAL BIOLOGY 16.8(2021):1390-1400.

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