Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512

doi:10.1002/cbdv.202100512

IOCAS-IR > 实验海洋生物学重点实验室

	Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512
	Chi, Lu-Ping1,2,3 ; Li, Xiao-Ming 1,2; Wan, Yu-Peng 1; Li, Yan-He1,2,3 ; Li, Xin1,2 ; Wang, Bin-Gui1,2,4
	2021-09-16
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
页码	6
通讯作者	Li, Xin([email protected]) ; Wang, Bin-Gui([email protected])
摘要	Two new phenol derivatives, namely insphenol A (1) and acetylpeniciphenol (2), along with seven known analogs (3-9), were isolated from the deep-sea cold seep-derived fungus, Aspergillus insuetus SD-512. The structures of 1 and 2 were established by extensive interpretation of NMR and mass spectroscopic data. The absolute configuration of 1 was determined by the combination of coupling constant analysis and acid hydrolysis. Among the isolated compounds, insphenol A (1) represents the first example of isopentenyl phenol derivative with a unique 1-glycosylation from the species Aspergillus insuetus. The isolated new compounds were evaluated for antibacterial activities against six human or aquatic pathogens, while compound 2 exhibited inhibitory effect against Edwardsiella tarda, Vibrio alginolyticus, and V. vulnificus, with MIC values of 4, 8, and 8 mu g/mL, respectively.
关键词	Aspergillus insuetus cold seep-derived fungus marine natural products antibacterial activity
DOI	10.1002/cbdv.202100512
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2018YFC0310800]; National Natural Science Foundation of China[42076090]; National Natural Science Foundation of China[U2006203]; Shandong Provincial Natural Science Foundation[ZR2019ZD18]; Basic Applied Research program of Qingdao[19-6-2-40-cg]; Senior User Project of RV KEXUE[KEXUE2020GZ02]; Center for Ocean Mega-Science, Chinese Academy of Sciences; Taishan Scholar Project from Shandong Province[ts201511060]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000696224300001
出版者	WILEY-V C H VERLAG GMBH
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/176389
专题	实验海洋生物学重点实验室
通讯作者	Li, Xin; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19 A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Chi, Lu-Ping,Li, Xiao-Ming,Wan, Yu-Peng,et al. Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512[J]. CHEMISTRY & BIODIVERSITY,2021:6.
APA	Chi, Lu-Ping,Li, Xiao-Ming,Wan, Yu-Peng,Li, Yan-He,Li, Xin,&Wang, Bin-Gui.(2021).Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512.CHEMISTRY & BIODIVERSITY,6.
MLA	Chi, Lu-Ping,et al."Two New Phenol Derivatives from the Cold Seep-Derived Fungus Aspergillus insuetus SD-512".CHEMISTRY & BIODIVERSITY (2021):6.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
cbdv.202100512.pdf（596KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览