Cytokines Induced by Edwardsiella tarda: Profile and Role in Antibacterial Immunity

doi:10.3390/biom11081242

IOCAS-IR > 实验海洋生物学重点实验室

	Cytokines Induced by Edwardsiella tarda: Profile and Role in Antibacterial Immunity
	Li, Huili1,2,3 ; Sun, Boguang1,2 ; Jiang, Shuai 1,2; Sun, Li 1,2,3
	2021-08-01
发表期刊	BIOMOLECULES
卷号	11 期号:8 页码:16
通讯作者	Sun, Li([email protected])
摘要	Edwardsiella tarda is a Gram-negative bacterial pathogen with a broad range of hosts, including fish and mammals. In the present study, we used an advanced antibody array technology to identify the expression pattern of cytokines induced by E. tarda in a mouse infection model. In total, 31 and 24 differentially expressed cytokines (DECs) were identified in the plasma at 6 h and 24 h post-infection (hpi), respectively. The DECs were markedly enriched in the Gene Ontology (GO) terms associated with cell migration and response to chemokine and in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with immunity, diseases, and infection. Ten key DECs, including IL6 and TNF-alpha , were found to form extensive protein-protein interaction networks. IL6 was demonstrated to inhibit E. tarda infection and be required for E. tarda-induced inflammatory response. TNF-alpha also exerted an inhibitory effect on E. tarda infection, and knockdown of fish (Japanese flounder) TNF-alpha promoted E. tarda invasion in host cells. Together, the results of this study revealed a comprehensive profile of cytokines induced by E. tarda, thus adding new insights into the role of cytokine-associated immunity against bacterial infection and also providing the potential plasma biomarkers of E. tarda infection for future studies.
关键词	cytokine Edwardsiella tarda infection antibody array immune response
DOI	10.3390/biom11081242
收录类别	SCI
语种	英语
资助项目	grants of the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao)[2018SDKJ0302-2]; National Key R&D Program of China[2018YFD0900500]; Youth Innovation Promotion Association CAS[2021204]; Taishan Scholar Program of Shandong Province
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:000688909800001
出版者	MDPI
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/176234
专题	实验海洋生物学重点实验室
通讯作者	Sun, Li
作者单位	1.Chinese Acad Sci, CAS Key Lab Expt Marine Biol, Inst Oceanol, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋大科学研究中心
通讯作者单位	中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Li, Huili,Sun, Boguang,Jiang, Shuai,et al. Cytokines Induced by Edwardsiella tarda: Profile and Role in Antibacterial Immunity[J]. BIOMOLECULES,2021,11(8):16.
APA	Li, Huili,Sun, Boguang,Jiang, Shuai,&Sun, Li.(2021).Cytokines Induced by Edwardsiella tarda: Profile and Role in Antibacterial Immunity.BIOMOLECULES,11(8),16.
MLA	Li, Huili,et al."Cytokines Induced by Edwardsiella tarda: Profile and Role in Antibacterial Immunity".BIOMOLECULES 11.8(2021):16.

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