Knowledge Management System Of Institute of Oceanology, Chinese Academy of Sciences
| Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants | |
Li, Xiaomin1,2,3,4; Xing, Ronge1,2,3,4 ; Xu, Chaojie1,2,3,4; Liu, Song1,2,3; Qin, Yukun1,2,3; Li, Kecheng1,2,3; Yu, Huahua1,2,3; Li, Pengcheng1,2,3
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| 2021-07-15 | |
| 发表期刊 | CARBOHYDRATE POLYMERS
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| ISSN | 0144-8617 |
| 卷号 | 264页码:16 |
| 通讯作者 | Xing, Ronge([email protected]) |
| 摘要 | Vaccines have always been the most effective preventive treatment. Advancements in the field of vaccine is inseparable from adjuvants. Adjuvants are substances added to vaccines to enhance immunogenicity and induce a stronger immune response. Chitosan fascinated considerable attention as vaccine adjuvant due to its unique physicochemical and biological properties. Many studies have shown that chitosan and its derivatives can effectively activate antigen-presenting cells and induce cytokine stimulation to produce an effective immune response and promote the balance of Th1/Th2 response. Among many derivatives, the quaternized chitosan performs better. This review presents the main factors affecting the adjuvant performance of chitosan and quaternized chitosan firstly. Then, we introduced not only the immune response they may cause, but also their metabolic research in detail. Furthermore, their future prospects are forecasted. Overall, chitosan and quaternized chitosan are both promising adjuvant materials, and quaternized chitosan shows greater potential. |
| 关键词 | Chitosan Quaternized chitosan Immunostimulatory activities Immune mechanism Vaccine adjuvant |
| DOI | 10.1016/j.carbpol.2021.118050 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Key R&D Program of China[2018YFC0311300]; Key Research and Development Program of Shandong Province[2019GHY112015]; Key Research and Development Program of Shandong Province[2019YYSP028] |
| WOS研究方向 | Chemistry ; Polymer Science |
| WOS类目 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| WOS记录号 | WOS:000647409300001 |
| 出版者 | ELSEVIER SCI LTD |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/170944 |
| 专题 | 中国科学院海洋研究所 |
| 通讯作者 | Xing, Ronge |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 通讯作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Li, Xiaomin,Xing, Ronge,Xu, Chaojie,et al. Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants[J]. CARBOHYDRATE POLYMERS,2021,264:16. |
| APA | Li, Xiaomin.,Xing, Ronge.,Xu, Chaojie.,Liu, Song.,Qin, Yukun.,...&Li, Pengcheng.(2021).Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants.CARBOHYDRATE POLYMERS,264,16. |
| MLA | Li, Xiaomin,et al."Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants".CARBOHYDRATE POLYMERS 264(2021):16. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 1-s2.0-S014486172100（5211KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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