The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia

doi:10.1186/s12915-020-00943-9

	The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia
	Song, Hao 1,2,3,4; Guo, Ximing 5; Sun, Lina 1,2,3,4,6; Wang, Qianghui 8; Han, Fengming 8; Wang, Haiyan 1,2,3,6; Wray, Gregory A.9; Davidson, Phillip 9; Wang, Qing 6,7; Hu, Zhi 1,2,6; Zhou, Cong1,2,6 ; Yu, Zhenglin 1,2,3,4; Yang, Meijie 1,2,6; Feng, Jie 1,2,3,4; Shi, Pu1,2,6 ; Zhou, Yi1,2,3,4,6 ; Zhang, Libin 1,2,3,4,6; Zhang, Tao1,2,3,4,6
	2021-01-25
发表期刊	BMC BIOLOGY
卷号	19 期号:1 页码:20
通讯作者	Zhang, Tao([email protected])
摘要	Background Inhibitors of apoptosis (IAPs) are critical regulators of programmed cell death that are essential for development, oncogenesis, and immune and stress responses. However, available knowledge regarding IAP is largely biased toward humans and model species, while the distribution, function, and evolutionary novelties of this gene family remain poorly understood in many taxa, including Mollusca, the second most speciose phylum of Metazoa. Results Here, we present a chromosome-level genome assembly of an economically significant bivalve, the hard clam Mercenaria mercenaria, which reveals an unexpected and dramatic expansion of the IAP gene family to 159 members, the largest IAP gene repertoire observed in any metazoan. Comparative genome analysis reveals that this massive expansion is characteristic of bivalves more generally. Reconstruction of the evolutionary history of molluscan IAP genes indicates that most originated in early metazoans and greatly expanded in Bivalvia through both lineage-specific tandem duplication and retroposition, with 37.1% of hard clam IAPs located on a single chromosome. The expanded IAPs have been subjected to frequent domain shuffling, which has in turn shaped their architectural diversity. Further, we observed that extant IAPs exhibit dynamic and orchestrated expression patterns among tissues and in response to different environmental stressors. Conclusions Our results suggest that sophisticated regulation of apoptosis enabled by the massive expansion and diversification of IAPs has been crucial for the evolutionary success of hard clam and other molluscan lineages, allowing them to cope with local environmental stresses. This study broadens our understanding of IAP proteins and expression diversity and provides novel resources for studying molluscan biology and IAP function and evolution.
关键词	IAP gene family Molecular evolution Mollusca Gene duplication Divergence
DOI	10.1186/s12915-020-00943-9
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2019YFD0900800]; earmarked fund for the Modern Agro-industry Technology Research System[CARS-49]; Major Applied Technology Innovation Project in Agriculture of Shandong Province[SF1405303301]; Supporting Program of Science and Technology Service Network Initiative in Fujian Province[2017 T3014]; Industry Leading Talents Project of Taishan Scholars; Double Hundred Blue Industry Leader Team of Yantai
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:000613072400002
出版者	BMC
引用统计	被引频次：54[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/170070
专题	海洋生态与环境科学重点实验室
通讯作者	Zhang, Tao
作者单位	1.Chinese Acad Sci, CAS Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China 5.Rutgers State Univ, Dept Marine & Coastal Sci, Haskin Shellfish Res Lab, Port Norris, NJ USA 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai 264003, Peoples R China 8.Novogene Bioinformat Inst, Beijing 100029, Peoples R China 9.Duke Univ, 130 Sci Dr, Durham, NC 27708 USA
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Song, Hao,Guo, Ximing,Sun, Lina,et al. The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia[J]. BMC BIOLOGY,2021,19(1):20.
APA	Song, Hao.,Guo, Ximing.,Sun, Lina.,Wang, Qianghui.,Han, Fengming.,...&Zhang, Tao.(2021).The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia.BMC BIOLOGY,19(1),20.
MLA	Song, Hao,et al."The hard clam genome reveals massive expansion and diversification of inhibitors of apoptosis in Bivalvia".BMC BIOLOGY 19.1(2021):20.

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