Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum

doi:10.3390/md19010009

IOCAS-IR > 实验海洋生物学重点实验室

	Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum
	Liu, Ya-Ping 1,2; Fang, Sheng-Tao 1; Shi, Zhen-Zhen 1; Wang, Bin-Gui3 ; Li, Xiao-Nian 4; Ji, Nai-Yun 1
	2021
发表期刊	MARINE DRUGS
卷号	19 期号:1 页码:10
通讯作者	Ji, Nai-Yun([email protected])
摘要	Three new phenylhydrazones, penoxahydrazones A-C (compounds 1-3), and two new quinazolines, penoxazolones A (compound 4) and B (compound 5), with unique linkages were isolated from the fungus Penicillium oxalicum obtained from the deep sea cold seep. Their structures and relative configurations were assigned by analysis of 1D/2D NMR and mass spectroscopic data, and the absolute configurations of 1, 4, and 5 were established on the basis of X-ray crystallography or ECD calculations. Compound 1 represents the first natural phenylhydrazone-bearing steroid, while compounds 2 and 3 are rarely occurring phenylhydrazone tautomers. Compounds 4 and 5 are enantiomers that feature quinazoline and cinnamic acid units. Some isolates exhibited inhibition of several marine phytoplankton species and marine-derived bacteria.
关键词	Penicillium oxalicum deep sea cold seep phenylhydrazone quinazoline
DOI	10.3390/md19010009
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2018YFC0310800]; Taishan Scholar Project[tsqn201909164]; Taishan Scholar Project[ts201511060]; Shuangbai Plan of Yantai[2018-3]; Youth Innovation Promotion Association of CAS[Y201734]; Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences[KEXUE2018G28]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000611035300001
出版者	MDPI
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/170005
专题	实验海洋生物学重点实验室
通讯作者	Ji, Nai-Yun
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Ctr Ocean Mega Sci, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Ctr Ocean Mega Sci, Inst Oceanol,Key Lab Expt Marine Biol,Lab Marine, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ya-Ping,Fang, Sheng-Tao,Shi, Zhen-Zhen,et al. Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum[J]. MARINE DRUGS,2021,19(1):10.
APA	Liu, Ya-Ping,Fang, Sheng-Tao,Shi, Zhen-Zhen,Wang, Bin-Gui,Li, Xiao-Nian,&Ji, Nai-Yun.(2021).Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum.MARINE DRUGS,19(1),10.
MLA	Liu, Ya-Ping,et al."Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum".MARINE DRUGS 19.1(2021):10.

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