Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichoderma virens QA-8

doi:10.3390/antibiotics10020213

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	Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichoderma virens QA-8
	Shi, Xiao-Shan1,2 ; Song, Yin-Ping 3; Meng, Ling-Hong1,2 ; Yang, Sui-Qun 1,2; Wang, Dun-Jia 4; Zhou, Xing-Wang 4; Ji, Nai-Yun 3,5; Wang, Bin-Gui1,2,5 ; Li, Xiao-Ming 1,2,5
	2021-02-01
发表期刊	ANTIBIOTICS-BASEL
ISSN	2079-6382
卷号	10 期号:2 页码:10
通讯作者	Wang, Bin-Gui([email protected]) ; Li, Xiao-Ming([email protected])
摘要	Carotane sesquiterpenes are commonly found in plants but are infrequently reported in the fungal kingdom. Chemical investigation of Trichoderma virens QA-8, an endophytic fungus associated with the inner root tissue of the grown medicinal herb Artemisia argyi H. Lev. and Vaniot, resulted in the isolation and characterization of five new carotane sesquiterpenes trichocarotins I-M (1-5), which have diverse substitution patterns, and seven known related analogues (6-12). The structures of these compounds were established on the basis of a detailed interpretation of their NMR and mass spectroscopic data, and the structures including the relative and absolute configurations of compounds 1-3, 5, 9, and 10 were confirmed by X-ray crystallographic analysis. In the antibacterial assays, all isolates exhibited potent activity against Escherichia coli EMBLC-1, with MIC values ranging from 0.5 to 32 mu g/mL, while 7 beta-hydroxy CAF-603 (7) strongly inhibited Micrococcus luteus QDIO-3 (MIC = 0.5 mu g/mL). Structure-activity relationships of these compounds were discussed. The results from this study demonstrate that the endophytic fungus T. virens QA-8 from the planted medicinal herb A. argyi is a rich source of antibacterial carotane sesquiterpenes, and some of them might be interesting for further study to be developed as novel antibacterial agents.
关键词	Artemisia argyi endophytic fungus Trichoderma virens carotane sesquiterpenes antibacterial activity
DOI	10.3390/antibiotics10020213
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31870328]
WOS研究方向	Infectious Diseases ; Pharmacology & Pharmacy
WOS类目	Infectious Diseases ; Pharmacology & Pharmacy
WOS记录号	WOS:000622009800001
出版者	MDPI
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/169589
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Li, Xiao-Ming
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 4.Hubei Normal Univ, Coll Chem & Chem Engn, Cihu Rd 11, Huangshi 435002, Hubei, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Shi, Xiao-Shan,Song, Yin-Ping,Meng, Ling-Hong,et al. Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichoderma virens QA-8[J]. ANTIBIOTICS-BASEL,2021,10(2):10.
APA	Shi, Xiao-Shan.,Song, Yin-Ping.,Meng, Ling-Hong.,Yang, Sui-Qun.,Wang, Dun-Jia.,...&Li, Xiao-Ming.(2021).Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichoderma virens QA-8.ANTIBIOTICS-BASEL,10(2),10.
MLA	Shi, Xiao-Shan,et al."Isolation and Characterization of Antibacterial Carotane Sesquiterpenes from Artemisia argyi Associated Endophytic Trichoderma virens QA-8".ANTIBIOTICS-BASEL 10.2(2021):10.

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