Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus Penicillium cyclopium SD-413

doi:10.3390/md18110553

IOCAS-IR > 实验海洋生物学重点实验室

	Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus Penicillium cyclopium SD-413
	Li, Yan-He1,2,3 ; Li, Xiao-Ming 1,2,4; Li, Xin1,2,4 ; Yang, Sui-Qun 1,2,4; Shi, Xiao-Shan1,2,4 ; Li, Hong-Lei1,2,4 ; Wang, Bin-Gui1,2,3
	2020-11-01
发表期刊	MARINE DRUGS
卷号	18 期号:11 页码:8
通讯作者	Li, Hong-Lei([email protected]) ; Wang, Bin-Gui([email protected])
摘要	Nine secondary metabolites (1-9), including two new polyketide derivatives 9-dehydroxysargassopenilline A (4) and 1,2-didehydropeaurantiogriseol E (5), along with seven known related secondary metabolites (1-3 and 6-9), were isolated and identified from the deep sea-derived fungus Penicillium cyclopium SD-413. Their structures were elucidated on the basis of 1D/2D NMR spectroscopic and mass spectrometric analysis and the absolute configurations were determined by the combination of NOESY correlations and time-dependent density functional (TDDFT) ECD calculations. Compounds 1-9 inhibited some pathogenic bacteria including Escherichia coli, E. ictaluri, Edwardsiella tarda, Micrococcus luteus, Vibrio anguillarum, and V. harveyi, with MIC (minimum inhibitory concentration) values ranging from 4 to 32 mu g/mL.
关键词	Penicillium cyclopium marine sediment-derived fungus quinazoline alkaloid polyketide derivatives antibacterial activity
DOI	10.3390/md18110553
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050401]; National Natural Science Foundation of China[31700043]; Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2016ASKJ14]; Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences[KEXUE2018G28]; Taishan Scholar Project from Shandong Province; Qingdao National Laboratory for Marine Science and Technology[OF2019NO03]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000593309800001
出版者	MDPI
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/169289
专题	实验海洋生物学重点实验室
通讯作者	Li, Hong-Lei; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Li, Yan-He,Li, Xiao-Ming,Li, Xin,et al. Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus Penicillium cyclopium SD-413[J]. MARINE DRUGS,2020,18(11):8.
APA	Li, Yan-He.,Li, Xiao-Ming.,Li, Xin.,Yang, Sui-Qun.,Shi, Xiao-Shan.,...&Wang, Bin-Gui.(2020).Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus Penicillium cyclopium SD-413.MARINE DRUGS,18(11),8.
MLA	Li, Yan-He,et al."Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus Penicillium cyclopium SD-413".MARINE DRUGS 18.11(2020):8.

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marinedrugs-18-00553（1506KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览