Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses | |
Lv, Zhao1,2,3; Qiu, Limei1,3; Wang, Weilin4,5,6 ; Liu, Zhaoqun4,5,6; Liu, Qing1,3; Wang, Lingling4,5,6; Song, Linsheng4,5,6
| |
| 2020-07-23 | |
| 发表期刊 | FRONTIERS IN IMMUNOLOGY
 |
| ISSN | 1664-3224 |
| 卷号 | 11页码:22 |
| 通讯作者 | Qiu, Limei([email protected]) ; Song, Linsheng([email protected]) |
| 摘要 | Studies on invertebrate immune receptors can provide insights into characteristics specific to innate immune system. Here, eight alpha and three beta integrins are identified from an invertebrate, the Pacific oysterCrassostrea gigas, and their possible immune functions are studied. Oyster alpha/beta integrins exhibit a higher degree of sequence and structural variability than the members fromHomo sapiensandDrosophila melanogaster. The analysis reveals that oyster RGD- and laminin-binding receptor homologs are present in the phylogenetic tree of alpha integrins, but the other six oyster alpha integrins mainly form a species-specific branch; meanwhile, oyster beta integrins are clustered with insect beta integrins but distinct from a member from the molluskBiomphalaria glabrata. Although phylogenetically lacking the important alpha integrin branches of LDV-binding, PS3-type, and alpha I-containing integrins, oyster integrins can bind to most ECM ligands, including RGDCP, LDVCP, GFOGERCP, and laminin protein in a distinct binding pattern. Besides, oyster integrins are distributed in different hemocyte subpopulations, while only specific integrins are selectively involved in hemocyte phagocytosis, migration, and encapsulation, and some of them participate in more than one immune response in a sophisticated pattern. Especially, oyster beta integrins are arranged in the core to mediate complex immune responses, unlike the counterparts in humans that mainly depend on alpha I-containing integrins to incite immune reactions. This study represents the first comprehensive attempt to reveal the structural and evolutionary features of the integrin family and their involvement in cellular immune responses in the non-model invertebrateC. gigasand sheds light on the characteristics specific to the innate immune system in the integrin family. |
| 关键词 | Crassostrea gigas integrin family immune function ECM ligand binding functional division and cooperation |
| DOI | 10.3389/fimmu.2020.01420 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[31530069]; Research Foundation for Talented Scholars in Dalian Ocean University; Earmarked Fund from Modern Agro-Industry Technology Research System[CARS-49] |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| WOS记录号 | WOS:000560065900001 |
| 出版者 | FRONTIERS MEDIA SA |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/168163 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Qiu, Limei; Song, Linsheng |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China 5.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol, Dalian, Peoples R China 6.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol & Dis Contro, Dalian, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所; 中国科学院海洋大科学研究中心 |
| 通讯作者单位 | 中国科学院海洋研究所; 中国科学院海洋大科学研究中心 |
| 推荐引用方式 GB/T 7714 | Lv, Zhao,Qiu, Limei,Wang, Weilin,et al. The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses[J]. FRONTIERS IN IMMUNOLOGY,2020,11:22. |
| APA | Lv, Zhao.,Qiu, Limei.,Wang, Weilin.,Liu, Zhaoqun.,Liu, Qing.,...&Song, Linsheng.(2020).The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses.FRONTIERS IN IMMUNOLOGY,11,22. |
| MLA | Lv, Zhao,et al."The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses".FRONTIERS IN IMMUNOLOGY 11(2020):22. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| The Members of the H（7265KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论