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| Cladocladosin A, an unusual macrolide with bicyclo 5/9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299 | |
Zhang, Fan-Zhong1,2 ; Li, Xiao-Ming1,2; Meng, Ling-Hong1,2; Wang, Bin-Gui1,2,3
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| 2020-08-01 | |
| 发表期刊 | BIOORGANIC CHEMISTRY
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| ISSN | 0045-2068 |
| 卷号 | 101页码:6 |
| 通讯作者 | Meng, Ling-Hong([email protected]) ; Wang, Bin-Gui([email protected]) |
| 摘要 | A simple but previously undescribed macrolide with unprecedented bicyclo 5/9 ring system, namely, clado-cladosin A (1), along with two new sulfur-containing macrolides, namely, thiocladospolides F and G (2 and 3), were characterized from the mangrove-derived endophytic fungus Cladosporium cladosporioides MA-299. The structures of these compounds were established on the basis of spectroscopic interpretation, and the absolute configurations of compounds 1-3 were determined by X-ray crystallographic analysis, Mosher's method, and by a biogenetic point of view. The possible biogenetic pathway for compounds 1-3 as well as their congeners thiocladospolides A-D and pandangolide 3 was proposed, providing a role in distinguishing the position of sulfur substitution in thiomacrolides. Compounds 1-3 were evaluated for antimicrobial activities against human-, aquatic-, and plant-pathogenic microbes. |
| 关键词 | Mangrove-derived Endophytic fungus Cladosporium cladosporioides Sulfur substitution Biogenetic pathway Antimicrobial activities |
| DOI | 10.1016/j.bioorg.2020.103950 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[81673351]; National Natural Science Foundation of China[31600267]; Natural Science Foundation of Shandong Province[ZR2016BQ17]; Taishan Scholar project from Shandong province |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Organic |
| WOS记录号 | WOS:000552629800012 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/168033 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Meng, Ling-Hong; Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Fan-Zhong,Li, Xiao-Ming,Meng, Ling-Hong,et al. Cladocladosin A, an unusual macrolide with bicyclo 5/9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299[J]. BIOORGANIC CHEMISTRY,2020,101:6. |
| APA | Zhang, Fan-Zhong,Li, Xiao-Ming,Meng, Ling-Hong,&Wang, Bin-Gui.(2020).Cladocladosin A, an unusual macrolide with bicyclo 5/9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299.BIOORGANIC CHEMISTRY,101,6. |
| MLA | Zhang, Fan-Zhong,et al."Cladocladosin A, an unusual macrolide with bicyclo 5/9 ring system, and two thiomacrolides from the marine mangrove-derived endophytic fungus, Cladosporium cladosporioides MA-299".BIOORGANIC CHEMISTRY 101(2020):6. |
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| Cladocladosin A, an （1833KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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