New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388

doi:10.1002/cbdv.202000320

IOCAS-IR > 实验海洋生物学重点实验室

	New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388
	Chi, Lu-Ping1,2,3 ; Li, Xiao-Ming 1,2; Li, Xin1,2 ; Wang, Bin-Gui1,2,4
	2020-07-20
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
页码	7
摘要	Two new antibacterial thiodiketopiperazine derivatives (TDKPs), 7-dehydroxyepicoccin H and 7-hydroxyeutypellazine F, along with seven known TDKP analogs, were isolated and identified fromEpicoccum nigrumSD-388, a deep-sea-sediment-derived fungus. The structures of these compounds were elucidated on the basis of detailed spectroscopic analysis. The absolute configuration of 7-dehydroxyepicoccin H was established by X-ray crystallographic analysis, while 7-hydroxyeutypellazine F was determined by ECD experiment and TDDFT-ECD calculation. The antibacterial activities against human and aquatic pathogens were evaluated. 7-Dehydroxyepicoccin H and 7-hydroxyeutypellazine F displayed inhibitory activities against aquatic pathogensVibrio vulnificus,V. alginolyticus, andEdwardsiella tarda, with MIC values ranging from 4.0 to 8.0 mu g/mL.
关键词	deep sea-derived fungus Epicoccum nigrum thiodiketopiperazines antibacterial activity
DOI	10.1002/cbdv.202000320
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050401]; Shandong Provincial Natural Science Foundation[ZR2019ZD18]; Basic Applied Research program of Qingdao[19-6-2-40-cg]; National Major Science and Technology Infrastructure from the Chinese Academy of Sciences[KEXUE2018G28]; Taishan Scholar Project from Shandong Province[ts201511060]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000550490700001
出版者	WILEY-V C H VERLAG GMBH
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/167952
专题	实验海洋生物学重点实验室
通讯作者	Li, Xin; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19 A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Chi, Lu-Ping,Li, Xiao-Ming,Li, Xin,et al. New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388[J]. CHEMISTRY & BIODIVERSITY,2020:7.
APA	Chi, Lu-Ping,Li, Xiao-Ming,Li, Xin,&Wang, Bin-Gui.(2020).New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388.CHEMISTRY & BIODIVERSITY,7.
MLA	Chi, Lu-Ping,et al."New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388".CHEMISTRY & BIODIVERSITY (2020):7.

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