Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species

doi:10.7554/eLife.53370

	Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species
	Wang, Tianming 1,2; Cao, Zheng 3; Shen, Zhangfei 3; Yang, Jingwen 1,2; Chen, Xu 1; Yang, Zhen 1; Xu, Ke 1; Xiang, Xiaowei 1; Yu, Qiuhan 1; Song, Yimin 1; Wang, Weiwei 3; Tian, Yanan 3; Sun, Lina 4; Zhang, Libin 4,5; Guo, Su 2; Zhou, Naiming 3
	2020-06-09
发表期刊	ELIFE
ISSN	2050-084X
卷号	9 页码:28
通讯作者	Wang, Tianming([email protected]) ; Zhou, Naiming([email protected])
摘要	The kisspeptin system is a central modulator of the hypothalamic-pituitary-gonadal axis in vertebrates. Its existence outside the vertebrate lineage remains largely unknown. Here, we report the identification and characterization of the kisspeptin system in the sea cucumber Apostichopus japonicus. The gene encoding the kisspeptin precursor generates two mature neuropeptides, AjKiss1a and AjKiss1b. The receptors for these neuropeptides, AjKissR1 and AjKissR2, are strongly activated by synthetic A. japonicus and vertebrate kisspeptins, triggering a rapid intracellular mobilization of Ca2+, followed by receptor internalization. AjKissR1 and AjKissR2 share similar intracellular signaling pathways via G(alpha q)/PLC/PKC/MAPK cascade, when activated by C-terminal decapeptide. The A. japonicus kisspeptin system functions in multiple tissues that are closely related to seasonal reproduction and metabolism. Overall, our findings uncover for the first time the existence and function of the kisspeptin system in a non-chordate species and provide new evidence to support the ancient origin of intracellular signaling and physiological functions that are mediated by this molecular system.
DOI	10.7554/eLife.53370
收录类别	SCI
语种	英语
资助项目	National Science Foundation of China[41876154]; National Science Foundation of China[41406137]; National Science Foundation of China[41606150]; Center for Ocean Mega-Research of Science, Chinese Acadamy of Science[COMS2019Q15]
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:000541447600001
出版者	ELIFE SCIENCES PUBLICATIONS LTD
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/167766
专题	海洋生态与环境科学重点实验室
通讯作者	Wang, Tianming; Zhou, Naiming
作者单位	1.Zhejiang Ocean Univ, Marine Sci Coll, Natl Engn Res Ctr Marine Facil Aquaculture, Zhoushan, Peoples R China 2.Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, Programs Human Genet & Biol Sci, San Francisco, CA 94143 USA 3.Zhejiang Univ, Coll Life Sci, Inst Biochem, Zijingang Campus, Hangzhou, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Wang, Tianming,Cao, Zheng,Shen, Zhangfei,et al. Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species[J]. ELIFE,2020,9:28.
APA	Wang, Tianming.,Cao, Zheng.,Shen, Zhangfei.,Yang, Jingwen.,Chen, Xu.,...&Zhou, Naiming.(2020).Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species.ELIFE,9,28.
MLA	Wang, Tianming,et al."Existence and functions of a kisspeptin neuropeptide signaling system in a non-chordate deuterostome species".ELIFE 9(2020):28.

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