| Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats | |
Qi, Huimin1,2; Liu, Xiaolei3; Wang, Kai1 ; Liu, Dongmei1; Huang, Liye4; Liu, Shunmei1; Zhang, Quanbin2; Zhang, QB
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| 2013-12-01 | |
| 发表期刊 | FOOD AND CHEMICAL TOXICOLOGY
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| ISSN | 0278-6915 |
| 卷号 | 62页码:573-578 |
| 文章类型 | Article |
| 摘要 | Ulvan extracted from Ulva pertusa (Chlorophyta) is a group of sulfated heteropolysaccharide, for simplicity, the sulfated polysaccharide is referred to as ulvan in this paper. To our knowledge, there is no detailed report investigating the toxicity of ulvan. In this study, the subchronic (6 months) toxicity of varying levels of ulvan extracted from U. pertusa was investigated in Wistar rats after oral administration. ALT, ALB, ALP, WBC, PLT, and liver relative organ weigh of female rats showed significantly difference at 3000 mg/kg body weight per day, compared with control group. On the other hand, TG, T-CHO concentrations of female rats (6 months) were significantly decreased at 600, 1200 and 3000 mg/kg body weight per day. This result proved that ulvan had antihyperlipidemic activity. Beside, ulvan showed anticoagulant activity in this study. Overall, our findings indicated that ulvan had affected specific hematology, serum biochemistry parameters and liver, and had great differences between males and females rats. (C) 2013 Elsevier Ltd. All rights reserved.; Ulvan extracted from Ulva pertusa (Chlorophyta) is a group of sulfated heteropolysaccharide, for simplicity, the sulfated polysaccharide is referred to as ulvan in this paper. To our knowledge, there is no detailed report investigating the toxicity of ulvan. In this study, the subchronic (6 months) toxicity of varying levels of ulvan extracted from U. pertusa was investigated in Wistar rats after oral administration. ALT, ALB, ALP, WBC, PLT, and liver relative organ weigh of female rats showed significantly difference at 3000 mg/kg body weight per day, compared with control group. On the other hand, TG, T-CHO concentrations of female rats (6 months) were significantly decreased at 600, 1200 and 3000 mg/kg body weight per day. This result proved that ulvan had antihyperlipidemic activity. Beside, ulvan showed anticoagulant activity in this study. Overall, our findings indicated that ulvan had affected specific hematology, serum biochemistry parameters and liver, and had great differences between males and females rats. (C) 2013 Elsevier Ltd. All rights reserved. |
| 关键词 | Ulvan Ulva Pertusa Subchronic Toxicity Rats |
| 学科领域 | Food Science & Technology ; Toxicology |
| DOI | 10.1016/j.fct.2013.09.022 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Food Science & Technology ; Toxicology |
| WOS类目 | Food Science & Technology ; Toxicology |
| WOS记录号 | WOS:000329960400075 |
| WOS关键词 | WEIGHT SULFATED POLYSACCHARIDES ; ANTIOXIDANT ACTIVITY ; FIBERS ; ALGAE |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/16722 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Zhang, QB |
| 作者单位 | 1.Weifang Med Univ, Weifang 261053, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Weifang Univ, Weifang 261061, Peoples R China 4.Shandong Inst Sci & Tech Informat, Jinan 250101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Huimin,Liu, Xiaolei,Wang, Kai,et al. Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats[J]. FOOD AND CHEMICAL TOXICOLOGY,2013,62:573-578. |
| APA | Qi, Huimin.,Liu, Xiaolei.,Wang, Kai.,Liu, Dongmei.,Huang, Liye.,...&Zhang, QB.(2013).Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats.FOOD AND CHEMICAL TOXICOLOGY,62,573-578. |
| MLA | Qi, Huimin,et al."Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats".FOOD AND CHEMICAL TOXICOLOGY 62(2013):573-578. |
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| Subchronic toxicity （345KB） | 限制开放 | CC BY-NC-SA | 浏览 | |||
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