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| Comparative Study of Fucoidan from Saccharina japonica and Its Depolymerized Fragment on Adriamycin-Induced Nephrotic Syndrome in Rats | |
Tan, Jiaojiao1,2,3 ; Wang, Jing1; Geng, Lihua1; Yue, Yang1; Wu, Ning1; Zhang, Quanbin1,2,3
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| 2020-03-01 | |
| 发表期刊 | MARINE DRUGS
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| 卷号 | 18期号:3页码:10 |
| 通讯作者 | Zhang, Quanbin([email protected]) |
| 摘要 | Nephrotic syndrome (NS) is a clinical syndrome with a variety of causes, mainly characterized by heavy proteinuria, hypoalbuminemia, and edema. At present, identification of effective and less toxic therapeutic interventions for nephrotic syndrome remains to be an important issue. In this study, we isolated fucoidan from Saccharina japonica and prepared its depolymerized fragment by oxidant degradation. Fucoidan and its depolymerized fragment had similar chemical constituents. Their average molecular weights were 136 and 9.5 kDa respectively. The effect of fucoidan and its depolymerized fragment on adriamycin-induced nephrotic syndrome were investigated in a rat model. The results showed that adriamycin-treated rats had heavy proteinuria and increased blood urea nitrogen (BUN), serum creatinine (SCr), total cholesterol (TC), and total triglyceride (TG) levels. Oral administration of fucoidan or low-molecular-weight fucoidan for 30 days could significantly inhibit proteinuria and decrease the elevated BUN, SCr, TG, and TC level in a dose-dependent manner. At the same dose (100 mg/kg), low-molecular-weight fucoidan had higher renoprotective activity than fucoidan. Their protective effect on nephrotic syndrome was partly related to their antioxidant activity. The results suggested that both fucoidan and its depolymerized fragment had excellent protective effect on adriamycin-induced nephrotic syndrome, and might have potential for the treatment of nephrotic syndrome. |
| 关键词 | fucoidan low-molecular-weight fucoidan adriamycin nephrotic syndrome |
| DOI | 10.3390/md18030137 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Key RD Plan of China[2018YFD0901104]; Major Scientific and Engineering Projects of Innovation in Shandong Province[2019JZZY010818]; STS Program of Chinese Academy of Sciences[KFJ-STS-QYZD-195]; K.C. Wong Education Foundation, CAS |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal |
| WOS记录号 | WOS:000524256300015 |
| 出版者 | MDPI |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/167215 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Zhang, Quanbin |
| 作者单位 | 1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院海洋大科学研究中心 |
| 通讯作者单位 | 中国科学院海洋大科学研究中心 |
| 推荐引用方式 GB/T 7714 | Tan, Jiaojiao,Wang, Jing,Geng, Lihua,et al. Comparative Study of Fucoidan from Saccharina japonica and Its Depolymerized Fragment on Adriamycin-Induced Nephrotic Syndrome in Rats[J]. MARINE DRUGS,2020,18(3):10. |
| APA | Tan, Jiaojiao,Wang, Jing,Geng, Lihua,Yue, Yang,Wu, Ning,&Zhang, Quanbin.(2020).Comparative Study of Fucoidan from Saccharina japonica and Its Depolymerized Fragment on Adriamycin-Induced Nephrotic Syndrome in Rats.MARINE DRUGS,18(3),10. |
| MLA | Tan, Jiaojiao,et al."Comparative Study of Fucoidan from Saccharina japonica and Its Depolymerized Fragment on Adriamycin-Induced Nephrotic Syndrome in Rats".MARINE DRUGS 18.3(2020):10. |
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