Cytotoxic Thiodiketopiperazine Derivatives from the Deep Sea-Derived Fungus Epicoccum nigrum SD-388

doi:10.3390/md18030160

IOCAS-IR > 实验海洋生物学重点实验室

	Cytotoxic Thiodiketopiperazine Derivatives from the Deep Sea-Derived Fungus Epicoccum nigrum SD-388
	Chi, Lu-Ping1,2,3 ; Li, Xiao-Ming 1,2; Li, Li 1,2,3; Li, Xin1,2 ; Wang, Bin-Gui1,2,4
	2020-03-01
发表期刊	MARINE DRUGS
卷号	18 期号:3 页码:12
通讯作者	Li, Xin([email protected]) ; Wang, Bin-Gui([email protected])
摘要	Four new thiodiketopiperazine alkaloids, namely, 5'-hydroxy-6'-ene-epicoccin G (1), 7-methoxy-7'-hydroxyepicoccin G (2), 8'-acetoxyepicoccin D (3), and 7'-demethoxyrostratin C (4), as well as a pair of new enantiomeric diketopiperazines, (+/-)-5-hydroxydiphenylalazine A (5), along with five known analogues (6-10), were isolated and identified from the culture extract of Epicoccum nigrum SD-388, a fungus obtained from deep-sea sediments (-4500 m). Their structures were established on the basis of detailed interpretation of the NMR spectroscopic and mass spectrometric data. X-ray crystallographic analysis confirmed the structures and established the absolute configurations of compounds 1-3, while the absolute configurations for compounds 4 and 5 were determined by ECD calculations. Compounds 4 and 10 showed potent activity against Huh7.5 liver tumor cells, which were comparable to that of the positive control, sorafenib, and the disulfide bridge at C-2/C-2' is likely essential for the activity.
关键词	Epicoccum nigrum deep-sea-derived fungus thiodiketopiperazines diketopiperazine enantiomers cytotocxic activity
DOI	10.3390/md18030160
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050401]; Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2016ASKJ14]; China Postdoctoral Science Foundation[2017M612360]; Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences[KEXUE2018G28]; Taishan Scholar Project from Shandong Province
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000524256300040
出版者	MDPI
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/167152
专题	实验海洋生物学重点实验室
通讯作者	Li, Xin; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Chi, Lu-Ping,Li, Xiao-Ming,Li, Li,et al. Cytotoxic Thiodiketopiperazine Derivatives from the Deep Sea-Derived Fungus Epicoccum nigrum SD-388[J]. MARINE DRUGS,2020,18(3):12.
APA	Chi, Lu-Ping,Li, Xiao-Ming,Li, Li,Li, Xin,&Wang, Bin-Gui.(2020).Cytotoxic Thiodiketopiperazine Derivatives from the Deep Sea-Derived Fungus Epicoccum nigrum SD-388.MARINE DRUGS,18(3),12.
MLA	Chi, Lu-Ping,et al."Cytotoxic Thiodiketopiperazine Derivatives from the Deep Sea-Derived Fungus Epicoccum nigrum SD-388".MARINE DRUGS 18.3(2020):12.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Cytotoxic Thiodiketo（2040KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览