| A comparative study of the anticoagulant activities of eleven fucoidans | |
Jin, Weihua1,2; Zhang, Quanbin1; Wang, Jing1,3 ; Zhang, Wenjing1,2; Zhang, QB
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| 2013-01-02 | |
| 发表期刊 | CARBOHYDRATE POLYMERS
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| ISSN | 0144-8617 |
| 卷号 | 91期号:1页码:1-6 |
| 文章类型 | Article |
| 摘要 | Seven fucoidans that differed only with respect to the average molecular weight and four fucoidans that differed with respect to both the molar ratio of fucose to galactose and the average molecular weight were obtained. The anticoagulant activities of these fucoidans were determined in order to understand the effects of the average molecular weight and the content of galactose. Fucoidans Y5-Y11, with the average molecular weight in the range of 50.1-8.4 kDa, showed decreasing activity at three concentrations and dose-dependent activity in the APTT and TT assays. Y1-Y4, which differed with respect to the average molecular weight and the molar ratio of fucose to galactose, exhibited complicated results in the APTT and TT assays. It was shown that not only the average molecular weight but also the molar ratio of fucose to galactose affected the anticoagulant activity of fucoidans. (C) 2012 Elsevier Ltd. All rights reserved.; Seven fucoidans that differed only with respect to the average molecular weight and four fucoidans that differed with respect to both the molar ratio of fucose to galactose and the average molecular weight were obtained. The anticoagulant activities of these fucoidans were determined in order to understand the effects of the average molecular weight and the content of galactose. Fucoidans Y5-Y11, with the average molecular weight in the range of 50.1-8.4 kDa, showed decreasing activity at three concentrations and dose-dependent activity in the APTT and TT assays. Y1-Y4, which differed with respect to the average molecular weight and the molar ratio of fucose to galactose, exhibited complicated results in the APTT and TT assays. It was shown that not only the average molecular weight but also the molar ratio of fucose to galactose affected the anticoagulant activity of fucoidans. (C) 2012 Elsevier Ltd. All rights reserved. |
| 关键词 | Fucoidan Molecular Weight Anticoagulant Activity |
| 学科领域 | Chemistry ; Polymer Science |
| DOI | 10.1016/j.carbpol.2012.07.067 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Chemistry ; Polymer Science |
| WOS类目 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| WOS记录号 | WOS:000310253800001 |
| WOS关键词 | BROWN-ALGAE ; LAMINARIA-JAPONICA ; POLYSACCHARIDES ; SULFATE |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/16683 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Zhang, QB |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Nantong Marine Sci & Technol R&D Ctr, Iocas 226006, Jiangsu, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Jin, Weihua,Zhang, Quanbin,Wang, Jing,et al. A comparative study of the anticoagulant activities of eleven fucoidans[J]. CARBOHYDRATE POLYMERS,2013,91(1):1-6. |
| APA | Jin, Weihua,Zhang, Quanbin,Wang, Jing,Zhang, Wenjing,&Zhang, QB.(2013).A comparative study of the anticoagulant activities of eleven fucoidans.CARBOHYDRATE POLYMERS,91(1),1-6. |
| MLA | Jin, Weihua,et al."A comparative study of the anticoagulant activities of eleven fucoidans".CARBOHYDRATE POLYMERS 91.1(2013):1-6. |
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| A comparative study （298KB） | 限制开放 | CC BY-NC-SA | 浏览 | |||
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