Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| THE EFFECT OF KELP ON SERUM LIPIDS OF HYPERLIPIDEMIA IN RATS | |
| Xu, Xinying1; Yu, Zhuqin1; Shuai, Li2; Guo, Yunliang1; Duan, Delin3; Fu, Pengfei4; Guo, YL | |
| 2013-04-01 | |
| 发表期刊 | JOURNAL OF FOOD BIOCHEMISTRY
 |
| ISSN | 0145-8884 |
| 卷号 | 37期号:2页码:129-135 |
| 文章类型 | Article |
| 摘要 | Hyperlipidemia is one kind of common and frequently occurring syndromes and closely related to cardiovascular and cerebrovascular disease occurrences in the world. It is significant to explore the marine foods and potential drug resources for the application in treating the hyperlipidemia. We conducted this study to investigate the reducing effect and mechanism of kelp (Saccharina japonica) on serum lipid of rat models with hyperlipidemia induced by a fat-rich diet. The levels of serum lipid including the triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were detected by biochemical assay. Enzyme-linked immunosorbent assay was applied to determine the level of oxidized LDL (ox-LDL). The activity of lipoprotein lipase (LPL) and hepatic lipase (HL) was determined by chemical colorimetry. The concentrations of malondialdehyde (MDA) and nitric oxide (NO) were respectively measured by thiobarbituric acid assay and nitrate reductase assay. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were respectively determined by xanthinoxidase assay and chemical colorimetry. The results showed that the serum levels of TG, TC and LDL decreased, while HDL increased significantly in treated group compared with those of model groups (P<0.05). The value of ox-LDL of treated groups was much lower than that of model groups (P<0.05). The activities of LPL and HL in serum and hepatic tissue in treated groups were significantly higher than those of model groups (P<0.05). The levels of MDA and NO in serum and hepatic tissue were lower than those of model groups (P<0.05), while the activities of SOD and GSH-PX were significantly higher than those of model groups (P<0.05). Our study indicated that kelp may correlate with the metabolism of TG, TC, LDL and HDL by enhancing the activities of LPL and HL, and regulate the levels of serum lipids by increasing the activities of SOD and GSH-PX to reduce the levels of MDA and NO. PRACTICAL APPLICATIONS The objective of this work is to explore the potential application of kelp for treating hyperlipidemia. It is showed that the kelp could regulate to the normal level of triglyceride, total cholesterol, low-density lipoprotein and high-density lipoprotein in the models. It also could enhance the activity of the lipoprotein lipase and hepatic lipase to change the oxidative stress.; Hyperlipidemia is one kind of common and frequently occurring syndromes and closely related to cardiovascular and cerebrovascular disease occurrences in the world. It is significant to explore the marine foods and potential drug resources for the application in treating the hyperlipidemia. We conducted this study to investigate the reducing effect and mechanism of kelp (Saccharina japonica) on serum lipid of rat models with hyperlipidemia induced by a fat-rich diet. The levels of serum lipid including the triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were detected by biochemical assay. Enzyme-linked immunosorbent assay was applied to determine the level of oxidized LDL (ox-LDL). The activity of lipoprotein lipase (LPL) and hepatic lipase (HL) was determined by chemical colorimetry. The concentrations of malondialdehyde (MDA) and nitric oxide (NO) were respectively measured by thiobarbituric acid assay and nitrate reductase assay. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) were respectively determined by xanthinoxidase assay and chemical colorimetry. The results showed that the serum levels of TG, TC and LDL decreased, while HDL increased significantly in treated group compared with those of model groups (P<0.05). The value of ox-LDL of treated groups was much lower than that of model groups (P<0.05). The activities of LPL and HL in serum and hepatic tissue in treated groups were significantly higher than those of model groups (P<0.05). The levels of MDA and NO in serum and hepatic tissue were lower than those of model groups (P<0.05), while the activities of SOD and GSH-PX were significantly higher than those of model groups (P<0.05). Our study indicated that kelp may correlate with the metabolism of TG, TC, LDL and HDL by enhancing the activities of LPL and HL, and regulate the levels of serum lipids by increasing the activities of SOD and GSH-PX to reduce the levels of MDA and NO. PRACTICAL APPLICATIONS The objective of this work is to explore the potential application of kelp for treating hyperlipidemia. It is showed that the kelp could regulate to the normal level of triglyceride, total cholesterol, low-density lipoprotein and high-density lipoprotein in the models. It also could enhance the activity of the lipoprotein lipase and hepatic lipase to change the oxidative stress. |
| 学科领域 | Biochemistry & Molecular Biology ; Food Science & Technology |
| DOI | 10.1111/j.1745-4514.2011.00606.x |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Biochemistry & Molecular Biology ; Food Science & Technology |
| WOS类目 | Biochemistry & Molecular Biology ; Food Science & Technology |
| WOS记录号 | WOS:000317017500001 |
| WOS关键词 | PERIPHERAL ARTERIAL-DISEASE ; GLUTATHIONE-PEROXIDASE ; DENSITY-LIPOPROTEIN ; LAMINARIA-JAPONICA ; FUCOIDAN |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/16645 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Guo, YL |
| 作者单位 | 1.Qingdao Univ, Inst Cerebrovasc Dis, Affiliated Hosp, Coll Med, Qingdao 266003, Shandong, Peoples R China 2.Qingdao Univ, Sch Chem Chem Engn & Environm Sci, Qingdao 266003, Shandong, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China 4.Shandong Haizhibao Marine Sci & Tech Ltd Co, Rongcheng, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Xinying,Yu, Zhuqin,Shuai, Li,et al. THE EFFECT OF KELP ON SERUM LIPIDS OF HYPERLIPIDEMIA IN RATS[J]. JOURNAL OF FOOD BIOCHEMISTRY,2013,37(2):129-135. |
| APA | Xu, Xinying.,Yu, Zhuqin.,Shuai, Li.,Guo, Yunliang.,Duan, Delin.,...&Guo, YL.(2013).THE EFFECT OF KELP ON SERUM LIPIDS OF HYPERLIPIDEMIA IN RATS.JOURNAL OF FOOD BIOCHEMISTRY,37(2),129-135. |
| MLA | Xu, Xinying,et al."THE EFFECT OF KELP ON SERUM LIPIDS OF HYPERLIPIDEMIA IN RATS".JOURNAL OF FOOD BIOCHEMISTRY 37.2(2013):129-135. |
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