Signaling pathways regulating innate immune responses in shrimp

doi:10.1016/j.fsi.2012.08.023

IOCAS-IR > 实验海洋生物学重点实验室

	Signaling pathways regulating innate immune responses in shrimp
	Li, Fuhua; Xiang, Jianhai; Xiang, JH
	2013-04-01
发表期刊	FISH & SHELLFISH IMMUNOLOGY
ISSN	1050-4648
卷号	34 期号:4 页码:973-980
文章类型	Article
摘要	The first line of defense against microbial infections in animals is innate immune response which triggers diverse humoral and cellular activities via signal transduction pathways. Toll, IMD and JAK/STAT pathways are regarded as the main pathways regulating the immune response of invertebrates. This paper reviews the main progress of the investigation on the immune response to pathogen's infection in shrimp and supposes that these three signal pathways exist in shrimp. Most of the components (proteins or genes) involved in Toll pathway of Drosophila have been cloned also in shrimp which suggested the existence of Toll pathway in shrimp. The data update shows that the Toll pathway of shrimp is responsive not only to Gram-positive bacteria, Gram-negative bacteria,. but also to WSSV. Challenge of WSSV can lead to the variation of transcription level of all identified components in shrimp Toll pathway, which supported that Toll pathway in shrimp played important roles during WSSV infection. Two major. homologs to the components of IMD pathway of Drosophila, IMD and Relish, have been identified in shrimp, which indicated that IMD pathway should be existed in shrimp and might play important roles in regulating the immune response of shrimp to bacteria and virus infection. Relish in IMD pathway and dorsal in Toll pathway of shrimp were both involved in the immune response of shrimp to bacteria and virus infection, which implied that these two pathways are not completely separated during the immune response of shrimp. The transcription of STAT in shrimp was modulated after WSSV infection, which suggested that a putative JAK/STAT pathway might exist in shrimp and be very important to virus infection. Study on the signaling pathway regulating the immune response in shrimp could help us to understand the innate immune system, and would provide instructions to shrimp disease control. Obviously, to get more clear ideas about the innate immunological pathways in shrimp, more solid functional studies should be done in the future. (C) 2012 Elsevier Ltd. All rights reserved.; The first line of defense against microbial infections in animals is innate immune response which triggers diverse humoral and cellular activities via signal transduction pathways. Toll, IMD and JAK/STAT pathways are regarded as the main pathways regulating the immune response of invertebrates. This paper reviews the main progress of the investigation on the immune response to pathogen's infection in shrimp and supposes that these three signal pathways exist in shrimp. Most of the components (proteins or genes) involved in Toll pathway of Drosophila have been cloned also in shrimp which suggested the existence of Toll pathway in shrimp. The data update shows that the Toll pathway of shrimp is responsive not only to Gram-positive bacteria, Gram-negative bacteria,. but also to WSSV. Challenge of WSSV can lead to the variation of transcription level of all identified components in shrimp Toll pathway, which supported that Toll pathway in shrimp played important roles during WSSV infection. Two major. homologs to the components of IMD pathway of Drosophila, IMD and Relish, have been identified in shrimp, which indicated that IMD pathway should be existed in shrimp and might play important roles in regulating the immune response of shrimp to bacteria and virus infection. Relish in IMD pathway and dorsal in Toll pathway of shrimp were both involved in the immune response of shrimp to bacteria and virus infection, which implied that these two pathways are not completely separated during the immune response of shrimp. The transcription of STAT in shrimp was modulated after WSSV infection, which suggested that a putative JAK/STAT pathway might exist in shrimp and be very important to virus infection. Study on the signaling pathway regulating the immune response in shrimp could help us to understand the innate immune system, and would provide instructions to shrimp disease control. Obviously, to get more clear ideas about the innate immunological pathways in shrimp, more solid functional studies should be done in the future. (C) 2012 Elsevier Ltd. All rights reserved.
关键词	Innate Immunity Signaling Pathway Bacteria Wssv Shrimp
学科领域	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
DOI	10.1016/j.fsi.2012.08.023
URL	查看原文
收录类别	SCI
语种	英语
WOS研究方向	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS类目	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS记录号	WOS:000325955900004
WOS关键词	SPOT SYNDROME VIRUS ; ANTIMICROBIAL PEPTIDE GENES ; TOLL-LIKE RECEPTORS ; SUPPRESSION SUBTRACTIVE HYBRIDIZATION ; FENNEROPENAEUS-CHINENSIS RESPONSE ; COMPARATIVE PROTEOMIC PROFILES ; DROSOPHILA HOST-DEFENSE ; NF-KAPPA-B ; LITOPENAEUS-VANNAMEI ; PENAEUS-MONODON
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
引用统计	被引频次：305[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/16632
专题	实验海洋生物学重点实验室
通讯作者	Xiang, JH
作者单位	Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
第一作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Li, Fuhua,Xiang, Jianhai,Xiang, JH. Signaling pathways regulating innate immune responses in shrimp[J]. FISH & SHELLFISH IMMUNOLOGY,2013,34(4):973-980.
APA	Li, Fuhua,Xiang, Jianhai,&Xiang, JH.(2013).Signaling pathways regulating innate immune responses in shrimp.FISH & SHELLFISH IMMUNOLOGY,34(4),973-980.
MLA	Li, Fuhua,et al."Signaling pathways regulating innate immune responses in shrimp".FISH & SHELLFISH IMMUNOLOGY 34.4(2013):973-980.

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