Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132 | |
Liu, Dong1,2; Li, Xiao-Ming1; Li, Chun-Shun1; Wang, Bin-Gui1 ; Wang, BG
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| 2013-06-01 | |
| 发表期刊 | HELVETICA CHIMICA ACTA
 |
| ISSN | 0018-019X |
| 卷号 | 96期号:6页码:1055-1061 |
| 文章类型 | Article |
| 摘要 | Two new 6,8(14),22-hexadehydro-5,9-epidioxy-3,15-dihydroxy sterols, nigerasterols A and B (1 and 2, resp.), together with two known cyclopentapeptides, malformins A1 and C (3 and 4, resp.), were identified in the culture extract of Aspergillus niger MA-132, an endophytic fungus isolated from a fresh healthy sample of the mangrove plant Avicennia marina. The structures and relative configurations of these compounds were established on the basis of extensive spectroscopic analyses. The absolute configuration of compound 1 was determined by application of a modified version of Mosher's method. Nigerasterols A and B (1 and 2, resp.) represent the first 5,9-epidioxy-sterol compounds of marine origin, and they displayed potent activity against tumor cell lines HL60 and A549 in a preliminary bioassay.; Two new 6,8(14),22-hexadehydro-5,9-epidioxy-3,15-dihydroxy sterols, nigerasterols A and B (1 and 2, resp.), together with two known cyclopentapeptides, malformins A1 and C (3 and 4, resp.), were identified in the culture extract of Aspergillus niger MA-132, an endophytic fungus isolated from a fresh healthy sample of the mangrove plant Avicennia marina. The structures and relative configurations of these compounds were established on the basis of extensive spectroscopic analyses. The absolute configuration of compound 1 was determined by application of a modified version of Mosher's method. Nigerasterols A and B (1 and 2, resp.) represent the first 5,9-epidioxy-sterol compounds of marine origin, and they displayed potent activity against tumor cell lines HL60 and A549 in a preliminary bioassay. |
| 关键词 | Aspergillus Niger Ma-132 Avicennia Marina Fungi Nigerasterols a And b Antiproliferative Activity |
| 学科领域 | Chemistry |
| DOI | 10.1002/hlca.201200332 |
| URL | 查看原文 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| WOS记录号 | WOS:000320611900006 |
| WOS关键词 | PENICILLIUM-CHRYSOGENUM QEN-24S ; EDIBLE MUSHROOMS ; CHAETOMIUM-GLOBOSUM ; MARINE ; DERIVATIVES ; ANTIFUNGAL ; METABOLITE ; SPONGE ; ASSAY |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/16609 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Wang, BG |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Dong,Li, Xiao-Ming,Li, Chun-Shun,et al. Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132[J]. HELVETICA CHIMICA ACTA,2013,96(6):1055-1061. |
| APA | Liu, Dong,Li, Xiao-Ming,Li, Chun-Shun,Wang, Bin-Gui,&Wang, BG.(2013).Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132.HELVETICA CHIMICA ACTA,96(6),1055-1061. |
| MLA | Liu, Dong,et al."Nigerasterols A and B, Antiproliferative Sterols from the Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132".HELVETICA CHIMICA ACTA 96.6(2013):1055-1061. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Nigerasterols A and （185KB） | 限制开放 | CC BY-NC-SA | 浏览 | |||
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