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| Exceptionally high cumulative percentage of NUMTs originating from linear mitochondrial DNA molecules in the Hydra magnipapillata genome | |
| Song, Shen1; Jiang, Feng2,3; Yuan, Jianbo4; Guo, Wei2; Miao, Yongwang1; Jiang, F | |
| 2013-07-04 | |
| 发表期刊 | BMC GENOMICS
 |
| ISSN | 1471-2164 |
| 卷号 | 14页码:447 |
| 文章类型 | Article |
| 摘要 | Background: In contrast to most animal genomes, mitochondrial genomes in species belonging to the phylum Cnidaria show distinct variations in genome structure, including the mtDNA structure (linear or circular) and the presence or absence of introns in protein-coding genes. Therefore, the analysis of nuclear insertions of mitochondrial sequences (NUMTs) in cnidarians allows us to compare the NUMT content in animals with different mitochondrial genome structures.; Background: In contrast to most animal genomes, mitochondrial genomes in species belonging to the phylum Cnidaria show distinct variations in genome structure, including the mtDNA structure (linear or circular) and the presence or absence of introns in protein-coding genes. Therefore, the analysis of nuclear insertions of mitochondrial sequences (NUMTs) in cnidarians allows us to compare the NUMT content in animals with different mitochondrial genome structures. Results: NUMT identification in the Hydra magnipapillata, Nematostella vectensis and Acropora digitifera genomes showed that the NUMT density in the H. magnipapillata genome clearly exceeds that in other two cnidarians with circular mitochondrial genomes. We found that H. magnipapillata is an exceptional ancestral metazoan with a high NUMT cumulative percentage but a large genome, and its mitochondrial genome linearisation might be responsible for the NUMT enrichment. We also detected the co-transposition of exonic and intronic fragments within NUMTs in N. vectensis and provided direct evidence that mitochondrial sequences can be transposed into the nuclear genome through DNA-mediated fragment transfer. In addition, NUMT expression analyses showed that NUMTs are co-expressed with adjacent protein-coding genes, suggesting the relevance of their biological function. Conclusions: Taken together, our results provide valuable information for understanding the impact of mitochondrial genome structure on the interaction of mitochondrial molecules and nuclear genomes. |
| 关键词 | Cnidaria Mitochondrial Dna Numt Linear Mitochondrial Genome |
| 学科领域 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| DOI | 10.1186/1471-2164-14-447 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS记录号 | WOS:000321861700002 |
| WOS关键词 | CLASS-LEVEL RELATIONSHIPS ; TRANSFER-RNA GENES ; KINASE-C-DELTA ; NUCLEAR GENOME ; SEGMENTAL DUPLICATIONS ; PHYLUM CNIDARIA ; TRNASCAN-SE ; EVOLUTION ; PSEUDOGENES ; SEQUENCES |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/16566 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Jiang, F |
| 作者单位 | 1.Yunnan Agr Univ, Fac Anim Sci & Technol, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Inst Zool, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Shen,Jiang, Feng,Yuan, Jianbo,et al. Exceptionally high cumulative percentage of NUMTs originating from linear mitochondrial DNA molecules in the Hydra magnipapillata genome[J]. BMC GENOMICS,2013,14:447. |
| APA | Song, Shen,Jiang, Feng,Yuan, Jianbo,Guo, Wei,Miao, Yongwang,&Jiang, F.(2013).Exceptionally high cumulative percentage of NUMTs originating from linear mitochondrial DNA molecules in the Hydra magnipapillata genome.BMC GENOMICS,14,447. |
| MLA | Song, Shen,et al."Exceptionally high cumulative percentage of NUMTs originating from linear mitochondrial DNA molecules in the Hydra magnipapillata genome".BMC GENOMICS 14(2013):447. |
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| Exceptionally high c（550KB） | 限制开放 | CC BY-NC-SA | 浏览 | |||
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