Aniquinazolines A-D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans

doi:10.3390/md11072682

IOCAS-IR > 实验海洋生物学重点实验室

	Aniquinazolines A-D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans
	An, Chun-Yan 1,2; Li, Xiao-Ming 1; Li, Chun-Shun 1; Wang, Ming-Hui 1,2; Xu, Gang-Ming 1; Wang, Bin-Gui1 ; Wang, BG
	2013-07-01
发表期刊	MARINE DRUGS
ISSN	1660-3397
卷号	11 期号:7 页码:2682-2694
文章类型	Article
摘要	Four new quinazolinone alkaloids, namely, aniquinazolines A-D (1-4), were isolated and identified from the culture of Aspergillus nidulans MA-143, an endophytic fungus obtained from the leaves of marine mangrove plant Rhizophora stylosa. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined on the basis of chiral HPLC analysis of the acidic hydrolysates. The structure for 1 was confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina) lethality.; Four new quinazolinone alkaloids, namely, aniquinazolines A-D (1-4), were isolated and identified from the culture of Aspergillus nidulans MA-143, an endophytic fungus obtained from the leaves of marine mangrove plant Rhizophora stylosa. The structures of the new compounds were elucidated by spectroscopic analysis, and their absolute configurations were determined on the basis of chiral HPLC analysis of the acidic hydrolysates. The structure for 1 was confirmed by single-crystal X-ray diffraction analysis. All these compounds were examined for antibacterial and cytotoxic activity as well as brine shrimp (Artemia salina) lethality.
关键词	Mangrove Endophytic Fungus Aspergillus Nidulans Secondary Metabolites Bioactivity
学科领域	Pharmacology & Pharmacy
DOI	10.3390/md11072682
URL	查看原文
收录类别	SCI
语种	英语
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000328621500026
WOS关键词	METABOLITES ; ANTIFUNGAL ; FUMIGATUS
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
引用统计	被引频次：45[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/16528
专题	实验海洋生物学重点实验室
通讯作者	Wang, BG
作者单位	1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	An, Chun-Yan,Li, Xiao-Ming,Li, Chun-Shun,et al. Aniquinazolines A-D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans[J]. MARINE DRUGS,2013,11(7):2682-2694.
APA	An, Chun-Yan.,Li, Xiao-Ming.,Li, Chun-Shun.,Wang, Ming-Hui.,Xu, Gang-Ming.,...&Wang, BG.(2013).Aniquinazolines A-D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans.MARINE DRUGS,11(7),2682-2694.
MLA	An, Chun-Yan,et al."Aniquinazolines A-D, Four New Quinazolinone Alkaloids from Marine-Derived Endophytic Fungus Aspergillus nidulans".MARINE DRUGS 11.7(2013):2682-2694.

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