Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster

doi:10.1016/j.fsi.2019.10.060

IOCAS-IR > 实验海洋生物学重点实验室

	Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster
	Tang, Xueying 1,3; Huang, Baoyu1,2,6 ; Lin, Siheng1,2 ; Wang, Wei 1,2,5,6; Zhang, Guofan 1,2,5,6; Li, Li 1,2,4,5,6
	2020
发表期刊	FISH & SHELLFISH IMMUNOLOGY
ISSN	1050-4648
卷号	96 页码:138-140
摘要	MyD88 is a universal adapter protein for the Toll-like receptor/interleukin-1 receptor (TLR/IL-1R) signaling pathway. Since invertebrates are believed to lack MyD88-independent pathways, MyD88 appears more critical in oyster TLR signaling pathway. In the Pacific oyster (Crassostrea gigas), two complete paralogues, named as CgMyD88-1 and CgMyD88-2, have been identified. In the current study, we indicated that CgMyD88-1 and CgMyD88-2 might act synergistically to increase the efficiency of immune signaling by activating NF-kappa B transcription factor. However, we found that upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid [poly (I:C)], CgMyD88-1 and CgMyD88-2 show differences in their response: CgMyD88-1 accumulated as large spots in the cytoplasm, while CgMyD88-2 assembled in the cytoplasm and in the membrane. Our results support the theory that expansion of these immune genes is associated with functional diversity.
关键词	Crassostrea gigas Innate immunity MyD88 Functional diversity
DOI	10.1016/j.fsi.2019.10.060
收录类别	SCI
语种	英语
资助项目	Scientific Research Staring Foundation of Minnan normal university[4206-L21829]###3705; Earmarked Fund for China Agricultural Research System[CARS-49]###3704; National Key R&D Program of China[2018YFD0900304]###2846; National Key R&D Program of China[2018YFD0900304]; Earmarked Fund for China Agricultural Research System[CARS-49]; Scientific Research Staring Foundation of Minnan normal university[4206-L21829]
WOS研究方向	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS类目	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS记录号	WOS:000509617400016
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/164485
专题	实验海洋生物学重点实验室
通讯作者	Li, Li
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Shandong, Peoples R China 3.Minnan Normal Univ, Dept Biol Sci & Biotechnol, Zhangzhou 363000, Fujian, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Shandong, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China 6.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Shandong, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Tang, Xueying,Huang, Baoyu,Lin, Siheng,et al. Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster[J]. FISH & SHELLFISH IMMUNOLOGY,2020,96:138-140.
APA	Tang, Xueying,Huang, Baoyu,Lin, Siheng,Wang, Wei,Zhang, Guofan,&Li, Li.(2020).Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster.FISH & SHELLFISH IMMUNOLOGY,96,138-140.
MLA	Tang, Xueying,et al."Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster".FISH & SHELLFISH IMMUNOLOGY 96(2020):138-140.

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