Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance

doi:10.1007/s00253-019-10219-0

IOCAS-IR > 实验海洋生物学重点实验室

	Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance
	Xu, Gangming; Yang, Suiqun
	2019-12-01
发表期刊	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
ISSN	0175-7598
卷号	103 期号:23-24 页码:9373-9378
摘要	Bacteria modulate their physiological behavior by responding to various signal molecules. The signals are received by cognate receptors, which usually mediate transcriptional regulation. Streptomyces employ gamma-butyrolactones (GBLs) and cognate GBL receptors (GblRs) to regulate secondary metabolism and morphological development. However, there are additional transcriptional regulators called pseudo GblR regulators, which cannot bind GBLs and are not directly associated with GBL synthase. The pseudo GblR regulators may act as transcriptional repressors and respond to antibiotic signals. They play regulatory roles in coordination of antibiotic biosynthesis by connecting the hormone feed-forward loops and the antibiotic feedback loops. As the TetR family members, they might also have evolutionary roles between the transcriptional regulators of quorum sensing and antibiotic resistance. Understanding the regulatory and evolutionary roles of the pseudo GblR family would be helpful for fine-tuning regulation of antibiotic biosynthesis and resistance.
关键词	Microbial hormone gamma-butyrolactone Quorum sensing Antibiotic resistance
DOI	10.1007/s00253-019-10219-0
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31200042]###3669; National Natural Science Foundation of China[31570038]###3668; National Natural Science Foundation of China[31570038]; National Natural Science Foundation of China[31200042]
WOS研究方向	Biotechnology & Applied Microbiology
WOS类目	Biotechnology & Applied Microbiology
WOS记录号	WOS:000509524600014
出版者	SPRINGER
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/164422
专题	实验海洋生物学重点实验室
通讯作者	Xu, Gangming
作者单位	Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Xu, Gangming,Yang, Suiqun. Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2019,103(23-24):9373-9378.
APA	Xu, Gangming,&Yang, Suiqun.(2019).Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,103(23-24),9373-9378.
MLA	Xu, Gangming,et al."Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 103.23-24(2019):9373-9378.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Regulatory and evolu（617KB）	期刊论文	作者接受稿	限制开放	CC BY-NC-SA	浏览