Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Dietary beta-glucan modulate haematological parameters, cytokines and gene expression in TLR and ERK pathways of rainbow trout (Oncorhynchus mykiss) during infection by Aeromonas salmonicida | |
Ji, Liqin1,2,3,4; Fu, Songzhe5; Sun, Guoxiang1; Li, Xian1,2,4; Liu, Ying2,5
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| 2019-12-13 | |
| 发表期刊 | AQUACULTURE RESEARCH
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| ISSN | 1355-557X |
| 页码 | 12 |
| 摘要 | To explore the role of beta-glucan (0, 0.05%, 0.1% and 0.2%) in resisting bacteria, rainbow trout (Oncorhynchus mykiss) was challenged with Aeromonas salmonicida after 42-day beta-glucan administration, and then sampled at 0, 2, 4 and 6 days post infection (dpi). The data showed that 0.2% beta-glucan reduced the accumulated mortality rates compared with the ICG (infected control group) (p ). The white blood cells, red blood cells and haemoglobin were higher in the 0.2% beta-glucan group (BG) than the ICG (p ). 0.1% and 0.2% beta-glucan elevated serum total antioxidative capability and glutathione activity but alleviated the increase of serum alkaline phosphatase activity and glucose concentration (p < .05) during infection. Serum TNF-alpha, IL-1 beta, IL-8 and IgM in three BGs elevated remarkably on 6 dpi compared with the ICG (p ). Expression of tnf, il1b and cxcl8 of the head kidney in the 0.1% and 0.2% BGs was higher than the ICG on 4 dpi while ighm expression in the 0.2% BG was higher than in the ICG on 2 and 6 dpi (p ). 0.1% and 0.2% beta-glucan increased the expression of tlr5m, tlr5s, tmek and myd88 in the spleen after infection (p < .05). Similarly, 0.2% beta-glucan up-regulated the expression of tmek, myd88, oncmyk-dab and c3 in head kidney (p < .05). Overall, 0.2% dietary beta-glucan effectively decreased accumulated mortality rate by modulating the biochemistry process, cytokines, and activating TLR and ERK signalling pathways during A. salmonicida infection. |
| 关键词 | Aeromonas salmonicida cytokines rainbow trout TLR and ERK signalling pathways beta-glucans |
| DOI | 10.1111/are.14436 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Founds[31672673]###3398; Key R&D Program of Guangdong Province[2019B020215001]###3397; Key Technologies R&D Program of Shandong Province[2018GHY115031]###673; National Key Technologies RD Program[2017YFB0404000]###672; National Key R&D Program of China[2017YFD0701700]###440; National Key R&D Program of China[2017YFD0701700]; National Key Technologies RD Program[2017YFB0404000]; Key Technologies R&D Program of Shandong Province[2018GHY115031]; Key R&D Program of Guangdong Province[2019B020215001]; National Natural Science Founds[31672673] |
| WOS研究方向 | Fisheries |
| WOS类目 | Fisheries |
| WOS记录号 | WOS:000502358400001 |
| 出版者 | WILEY |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/163751 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Liu, Ying |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Shandong, Peoples R China 5.Dalian Ocean Univ, Sch Marine Sci & Environm Engn, 52 Heroitte St, Dalian 116023, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所; 中国科学院海洋大科学研究中心 |
| 推荐引用方式 GB/T 7714 | Ji, Liqin,Fu, Songzhe,Sun, Guoxiang,et al. Dietary beta-glucan modulate haematological parameters, cytokines and gene expression in TLR and ERK pathways of rainbow trout (Oncorhynchus mykiss) during infection by Aeromonas salmonicida[J]. AQUACULTURE RESEARCH,2019:12. |
| APA | Ji, Liqin,Fu, Songzhe,Sun, Guoxiang,Li, Xian,&Liu, Ying.(2019).Dietary beta-glucan modulate haematological parameters, cytokines and gene expression in TLR and ERK pathways of rainbow trout (Oncorhynchus mykiss) during infection by Aeromonas salmonicida.AQUACULTURE RESEARCH,12. |
| MLA | Ji, Liqin,et al."Dietary beta-glucan modulate haematological parameters, cytokines and gene expression in TLR and ERK pathways of rainbow trout (Oncorhynchus mykiss) during infection by Aeromonas salmonicida".AQUACULTURE RESEARCH (2019):12. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Dietary β‐glucan mod（1766KB） | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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