| Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions |
| Shi, Xiaolin1,2,3; Li, Xiaowei1,2,3 ; Li, Xiangqian4; Shi, Dayong4
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| 2019-09-06
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| 发表期刊 | FRONTIERS IN CHEMISTRY
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| ISSN | 2296-2646
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| 卷号 | 7页码:10 |
| 通讯作者 | Li, Xiangqian([email protected])
; Shi, Dayong([email protected])
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| 摘要 | A highly selective copper-catalyzed trifluoromethylation of indoles is reported with the assistance of a removable directing group. This protocol provides an easy and rapid method to various 2-position-selective trifluoromethylated heteroarenes including indoles, pyrroles, benzofuran, and acetanilide. What is more, the reaction takes place at ambient conditions without any external ligand or additive. |
| 关键词 | C-H functionalization
trifluoromethylation
indoles
copper
radical reaction
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| DOI | 10.3389/fchem.2019.00613
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| 收录类别 | SCI
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| 语种 | 英语
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| 资助项目 | National Natural Science Foundation of China[81773586]###283; National Natural Science Foundation of China[81703354]###282; Key research and development project of Shandong province[2016GSF201193]###551; Key research and development project of Shandong province[2016ZDJS07A13]###285; Key research and development project of Shandong province[2016GSF115002]###552; Key research and development project of Shandong province[2016GSF115009]###553; CAS[QYZDB-SSW-DQC014]###3046; Project of Discovery, Evaluation and Transformation of Active Natural Compounds###2570; Chinese Academy of Sciences[ZSTH-026]###3047; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]###556; National Program for Support of Top-notch Young Professionals###557; Taishan scholar Youth Project of Shandong province###558; National Natural Science Foundation of China[81773586]; National Natural Science Foundation of China[81703354]; Key research and development project of Shandong province[2016GSF201193]; Key research and development project of Shandong province[2016ZDJS07A13]; Key research and development project of Shandong province[2016GSF115002]; Key research and development project of Shandong province[2016GSF115009]; CAS[QYZDB-SSW-DQC014]; Project of Discovery, Evaluation and Transformation of Active Natural Compounds; Chinese Academy of Sciences[ZSTH-026]; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]; National Program for Support of Top-notch Young Professionals; Taishan scholar Youth Project of Shandong province |
| WOS研究方向 | Chemistry
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| WOS类目 | Chemistry, Multidisciplinary
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| WOS记录号 | WOS:000484497100001
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| 出版者 | FRONTIERS MEDIA SA
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/162691
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| 专题 | 实验海洋生物学重点实验室
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| 通讯作者 | Li, Xiangqian; Shi, Dayong |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Shandong, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Shandong Univ, State Key Lab Microbial Technol, Qingdao, Shandong, Peoples R China
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| 第一作者单位 | 中国科学院海洋研究所
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推荐引用方式
GB/T 7714 |
Shi, Xiaolin,Li, Xiaowei,Li, Xiangqian,et al. Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions[J]. FRONTIERS IN CHEMISTRY,2019,7:10.
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| APA |
Shi, Xiaolin,Li, Xiaowei,Li, Xiangqian,&Shi, Dayong.(2019).Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions.FRONTIERS IN CHEMISTRY,7,10.
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| MLA |
Shi, Xiaolin,et al."Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions".FRONTIERS IN CHEMISTRY 7(2019):10.
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