The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus

doi:10.1080/01480545.2019.1620264

IOCAS-IR > 实验海洋生物学重点实验室

	The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus
	He, Xiaofei 1,2,3; Xing, Ronge1,2,3 ; Liu, Song 1,2,3; Qin, Yukun1,2,3 ; Li, Kecheng 1,2,3; Yu, Huahua1,2,3 ; Li, Pengcheng1,2,3
	2019-06-07
发表期刊	DRUG AND CHEMICAL TOXICOLOGY
ISSN	0148-0545
页码	6
通讯作者	Xing, Ronge([email protected])
摘要	Chitosan is widely used as a medical material because of its excellent biological activities. However, the low solubility of natural chitosan limited its medicinal activity to some extent. The solubility can be improved by introducing more active groups and lowering molecular weight. Therefore, 6-amine chitosan derivatives were synthesized in this paper since more active groups were introduced to increase the medicinal activity. Those derivatives were characterized by elemental analysis, HPLC, and FT-IR and the antiviral activity was tested by hemagglutination tests. Finally, 6-amine chitosan derivatives improved the antiviral activity, especially after the introduction of bromine ion. When 6-deoxy-6-bromo-N-phthaloyl chitosan was 1 g/L, they reduced the hemagglutination titer of virus to zero. The RT-PCR result showed that the expression level of TNF-alpha and IFN-beta increased significantly, which indicated that the antiviral activity of amino-modified chitosan worked through the stimulation of immune response.
关键词	6-Deoxy-6-bromo-N-phthaloyl chitosan antiviral activity Newcastle virus mechanism assumption
DOI	10.1080/01480545.2019.1620264
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2018YFC0311305]###203; Special projects of Foshan science and technology innovation team[2017IT100054]###204; National Key R&D Program of China[2018YFC0311305]; Special projects of Foshan science and technology innovation team[2017IT100054]
WOS研究方向	Chemistry ; Pharmacology & Pharmacy ; Toxicology
WOS类目	Chemistry, Multidisciplinary ; Pharmacology & Pharmacy ; Toxicology
WOS记录号	WOS:000473846600001
出版者	TAYLOR & FRANCIS LTD
引用统计	被引频次：47[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/161972
专题	实验海洋生物学重点实验室
通讯作者	Xing, Ronge
作者单位	1.Chinese Acad Sci, Ctr Ocean Mega Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Shandong, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Shandong, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	He, Xiaofei,Xing, Ronge,Liu, Song,et al. The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus[J]. DRUG AND CHEMICAL TOXICOLOGY,2019:6.
APA	He, Xiaofei.,Xing, Ronge.,Liu, Song.,Qin, Yukun.,Li, Kecheng.,...&Li, Pengcheng.(2019).The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus.DRUG AND CHEMICAL TOXICOLOGY,6.
MLA	He, Xiaofei,et al."The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus".DRUG AND CHEMICAL TOXICOLOGY (2019):6.

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