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| Thiocladospolides A-D, 12-Membered Macrolides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides MA-299 and Structure Revision of Pandangolide 3 | |
Zhang, Fan-Zhong1,2,3 ; Li, Xiao-Ming1,2; Yang, Sui-Qun1,2; Meng, Ling-Hong1,2; Wang, Bin-Gui1,2,3
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| 2019-06-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 82期号:6页码:1535-1541 |
| 通讯作者 | Meng, Ling-Hong([email protected]) ; Wang, Bin-Gui([email protected]) |
| 摘要 | Four new 12-membered macrolides, thiocladospolides A-D (1-4), each possessing a sulfur substitution at C-2, along with the known congener pandangolide 3 (5) and the possible hydrolysis product seco-patulolide C (6), were isolated and identified from the culture extract of Cladosporium cladosporioides MA-299, an endophytic fungus obtained from the leaves of the mangrove plant Bruguiera gymnorrhiza. Their structures were established by interpretation of the NMR spectroscopic and mass spectrometric data. X-ray crystallographic analysis of compound 1, which represents the first crystal structure described for a sulfur-containing 12-membered macrolide, confirmed its structure and absolute configuration. The proposed sulfur side chain at C-3 in pandangolide 3 (5) was revised to be at C-2 by detailed analysis of the NMR data and by a comparison with data for thiocladospolide A (1). The structures for pandangolides 2 and 4 should also be considered for revisions. The isolated compounds were evaluated for the antimicrobial activities against aquatic bacteria and plant pathogens. |
| DOI | 10.1021/acs.jnatprod.8b01091 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Natural Science Foundation of China[81673351]###1262; Natural Science Foundation of China[31600267]###1263; Natural Science Foundation of Shandong Province[ZR2016BQ17]###2822; Taishan Scholar Project from Shandong Province###1179; Natural Science Foundation of China[81673351]; Natural Science Foundation of China[31600267]; Natural Science Foundation of Shandong Province[ZR2016BQ17]; Taishan Scholar project from Shandong Province |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| WOS类目 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:000473827300017 |
| 出版者 | AMER CHEMICAL SOC |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/161954 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Meng, Ling-Hong; Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 通讯作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Fan-Zhong,Li, Xiao-Ming,Yang, Sui-Qun,et al. Thiocladospolides A-D, 12-Membered Macrolides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides MA-299 and Structure Revision of Pandangolide 3[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(6):1535-1541. |
| APA | Zhang, Fan-Zhong,Li, Xiao-Ming,Yang, Sui-Qun,Meng, Ling-Hong,&Wang, Bin-Gui.(2019).Thiocladospolides A-D, 12-Membered Macrolides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides MA-299 and Structure Revision of Pandangolide 3.JOURNAL OF NATURAL PRODUCTS,82(6),1535-1541. |
| MLA | Zhang, Fan-Zhong,et al."Thiocladospolides A-D, 12-Membered Macrolides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides MA-299 and Structure Revision of Pandangolide 3".JOURNAL OF NATURAL PRODUCTS 82.6(2019):1535-1541. |
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