Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides

doi:10.3390/md17050296

IOCAS-IR > 实验海洋生物学重点实验室

	Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides
	Zhang, Fan-Zhong1,2,3 ; Li, Xiao-Ming 1,2; Li, Xin1,2 ; Yang, Sui-Qun1,2 ; Meng, Ling-Hong1,2 ; Wang, Bin-Gui1,2,3
	2019-05-01
发表期刊	MARINE DRUGS
ISSN	1660-3397
卷号	17 期号:5 页码:13
通讯作者	Meng, Ling-Hong([email protected]) ; Wang, Bin-Gui([email protected])
摘要	Five new polyketides, namely, 5R-hydroxyrecifeiolide (1), 5S-hydroxyrecifeiolide (2), ent-cladospolide F (3), cladospolide G (4), and cladospolide H (5), along with two known compounds (6 and 7), were isolated from the endophytic fungal strain Cladosporium cladosporioides MA-299 that was obtained from the leaves of the mangrove plant Bruguiera gymnorrhiza. The structures of these compounds were established by extensive analysis of 1D/2D NMR data, mass spectrometric data, ECDs and optical rotations, and modified Mosher's method. The structures of 3 and 6 were confirmed by single-crystal X-ray diffraction analysis and this is the first time for reporting the crystal structures of these two compounds. All of the isolated compounds were examined for antimicrobial activities against human and aquatic bacteria and plant pathogenic fungi as well as enzymatic inhibitory activities against acetylcholinesterase. Compounds 1-4, 6, and 7 exhibited antimicrobial activity against some of the tested strains with MIC values ranging from 1.0 to 64 g/mL, while 3 exhibited enzymatic inhibitory activity against acetylcholinesterase with the IC50 value of 40.26 M.
关键词	mangrove plant endophytic fungus Cladosporium cladosporioides polyketides antimicrobial activity acetylcholinesterase enzymatic inhibitory activity
DOI	10.3390/md17050296
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of China[81673351]###1262; Natural Science Foundation of China[31600267]###1263; Natural Science Foundation of Shandong Province, China[ZR2016BQ17]###2791; Taishan Scholar Project from Shandong Province###1179; Natural Science Foundation of China[81673351]; Natural Science Foundation of China[31600267]; Natural Science Foundation of Shandong Province, China[ZR2016BQ17]; Taishan Scholar project from Shandong province
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000470964600049
出版者	MDPI
引用统计	被引频次：24[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/161820
专题	实验海洋生物学重点实验室
通讯作者	Meng, Ling-Hong; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Key Lab Expt Marine Biol, Ctr Ocean Mega Sci, Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Fan-Zhong,Li, Xiao-Ming,Li, Xin,et al. Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides[J]. MARINE DRUGS,2019,17(5):13.
APA	Zhang, Fan-Zhong,Li, Xiao-Ming,Li, Xin,Yang, Sui-Qun,Meng, Ling-Hong,&Wang, Bin-Gui.(2019).Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides.MARINE DRUGS,17(5),13.
MLA	Zhang, Fan-Zhong,et al."Polyketides from the Mangrove-Derived Endophytic Fungus Cladosporium cladosporioides".MARINE DRUGS 17.5(2019):13.

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