Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway

doi:10.3390/md17040207

IOCAS-IR > 实验海洋生物学重点实验室

	Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway
	Xu, Kuo 1; Guo, Chuanlong1,2 ; Meng, Jie1,3 ; Tian, Haiying 4; Guo, Shuju 1; Shi, Dayong 1,5
	2019-04-01
发表期刊	MARINE DRUGS
ISSN	1660-3397
卷号	17 期号:4 页码:11
通讯作者	Guo, Shuju([email protected]) ; Shi, Dayong([email protected])
摘要	A study on the secondary metabolites of Aspergillus sp. XNM-4, which was derived from marine algae Leathesia nana (Chordariaceae), led to the identification of one previously undescribed (1) and seventeen known compounds (2-18). Their planar structures were established by extensive spectroscopic analyses, while the stereochemical assignments were defined by electronic circular dichroism (ECD) calculations. The biological activities of the compounds were assessed on five human cancer cell lines (PANC-1, A549, MDA-MB-231, Caco-2, and SK-OV-3), and one human normal cell line (HL-7702) using an MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide] assay. Among them, the dimeric naphthopyrones 7, 10 and 12 exhibited potent cytotoxicity. Further mechanism studies showed that 12 induced apoptosis, arrested the cell cycle at the G0/G1 phase in the PANC-1 cells, caused morphological changes and generated ROS; and it induces PANC-1 cells apoptosis via ROS-mediated PI3K/Akt signaling pathway.
关键词	Aspergillus naphthopyrones cytotoxicity endophytic fungus Leathesia nana
DOI	10.3390/md17040207
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81803375]###586; National Postdoctoral Program for Innovative Talents[BX201700247]###587; China Postdoctoral Science Foundation[2018M630804]###588; Natural Science Foundation of Shandong Province[ZR2016DQ07]###589; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]###556; National Natural Science Foundation of China[81803375]; National Postdoctoral Program for Innovative Talents[BX201700247]; China Postdoctoral Science Foundation[2018M630804]; Natural Science Foundation of Shandong Province[ZR2016DQ07]; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000467307100014
出版者	MDPI
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/161356
专题	实验海洋生物学重点实验室
通讯作者	Guo, Shuju; Shi, Dayong
作者单位	1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Univ Sci & Technol, Coll Chem Engn, Dept Pharm, Qingdao 266042, Shandong, Peoples R China 3.Qingdao Agr Univ, Coll Resources & Environm, Qingdao 266109, Shandong, Peoples R China 4.China Tobacco Henan Ind Co Ltd, Technol Ctr, Zhengzhou 450000, Henan, Peoples R China 5.Shandong Univ, Sch Life Sci, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Xu, Kuo,Guo, Chuanlong,Meng, Jie,et al. Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway[J]. MARINE DRUGS,2019,17(4):11.
APA	Xu, Kuo,Guo, Chuanlong,Meng, Jie,Tian, Haiying,Guo, Shuju,&Shi, Dayong.(2019).Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway.MARINE DRUGS,17(4),11.
MLA	Xu, Kuo,et al."Discovery of Natural Dimeric Naphthopyrones as Potential Cytotoxic Agents through ROS-Mediated Apoptotic Pathway".MARINE DRUGS 17.4(2019):11.

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