Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Structural Revision of Wentiquinone C and Related Congeners from Anthraquinones to Xanthones Using Chemical Derivatization and NMR Analysis | |
Li, Xin1,2 ; Li, Xiao-Ming1,2; Wang, Bin-Gui1,2
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| 2019 | |
| 发表期刊 | MARINE DRUGS
 |
| ISSN | 1660-3397 |
| 卷号 | 17期号:1页码:8 |
| 通讯作者 | Wang, Bin-Gui([email protected]) |
| 摘要 | Wentiquinone C, which was previously isolated from the marine brown alga-derived endophytic fungus Aspergillus wentii EN-48, was found to be a potent antioxidant against ,-diphenyl-picrylhydrazyl (DPPH) radical. The structure of wentiquinone C was originally assigned as an anthraquinone derivative (1,10-dihydroxy-3-(hydroxymethyl)-8-methoxydibenzo [b,e]oxepine-6,11-dione, 1) by 1D and 2D NMR experiments. However, the minor differences of the chemical shifts between xanthones and anthraquinones were queried, leading to the structure of 1 to be revised as a xanthone analog (8-hydroxy-6-(hydroxymethyl)-3-methoxy-9-oxo-9H-xanthene-1-carboxylic acid, 2) on the basis of a methylation and subsequent NMR measurements, and was confirmed by X-ray crystallographic analysis. The method established in this paper could be applied to the structural re-examination or revision for some of the reported seco-anthraquinone derivatives. |
| 关键词 | Structure revision Wentiquinone C Methylation method Xanthones Anthraquinones Aspergillus wentii |
| DOI | 10.3390/md17010008 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Natural Science Foundation of China[31330009]###1180; Natural Science Foundation of China[41706182]###2464; Shandong Provincial Natural Science Foundation[ZR2017BB073]###2465; Natural Science Foundation of China[31330009]; Natural Science Foundation of China[41706182]; Shandong Provincial Natural Science Foundation[ZR2017BB073] |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal |
| WOS记录号 | WOS:000458053200008 |
| 出版者 | MDPI |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/160880 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Pilot Natl Lab Marine Sci & Technol Qingdao, Key Lab Expt Marine Biol, Inst Oceanol,Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 通讯作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Li, Xin,Li, Xiao-Ming,Wang, Bin-Gui. Structural Revision of Wentiquinone C and Related Congeners from Anthraquinones to Xanthones Using Chemical Derivatization and NMR Analysis[J]. MARINE DRUGS,2019,17(1):8. |
| APA | Li, Xin,Li, Xiao-Ming,&Wang, Bin-Gui.(2019).Structural Revision of Wentiquinone C and Related Congeners from Anthraquinones to Xanthones Using Chemical Derivatization and NMR Analysis.MARINE DRUGS,17(1),8. |
| MLA | Li, Xin,et al."Structural Revision of Wentiquinone C and Related Congeners from Anthraquinones to Xanthones Using Chemical Derivatization and NMR Analysis".MARINE DRUGS 17.1(2019):8. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Structural Revision （3104KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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