Knowledge Management System Of Institute of Oceanology, Chinese Academy of Sciences
| Responses of Antioxidant Defense and Immune Gene Expression in Early Life Stages of Large Yellow Croaker (Pseudosciaena crocea) Under Methyl Mercury Exposure | |
| Wu, Fangzhu1; Huang, Wei1; Liu, Qiang1; Xu, Xiaoqun1; Zeng, Jiangning1,2; Cao, Liang3; Hu, Ji1; Xu, Xudan1; Gao, Yuexin1; Jia, Shenghua1,4 | |
| 2018-10-10 | |
| 发表期刊 | FRONTIERS IN PHYSIOLOGY
 |
| ISSN | 1664-042X |
| 卷号 | 9页码:10 |
| 通讯作者 | Huang, Wei([email protected]) |
| 摘要 | Early life stages of marine organisms are the most sensitive stages to environment stressors including pollutants. In order to understand the toxicological effects induced by MeHg exposure on juveniles of large yellow croaker (Pseudosciaena crocea), a toxicity test was performed wherein fish were exposed to sub-lethal concentrations of MeHg under laboratory conditions (18 +/- 1 degrees C; 26 +/- 1 in salinity). After 30 days of 0-4.0 mu g L-1 MeHg exposure, SOD activity was significantly decreased in the 0.25, 1.0, and 4.0 mu g L-1 treatments; while CAT activity was significantly increased in the 4.0 mu g L-1 treatments; GSH level, GPx activity were significantly elevated in the 4.0 mu g L-1 treatments, respectively. Meanwhile, malondialdehyde content was also significantly increased in the 1.0 and 4.0 mu g L-1 treatments with respect to the control. Acetylcholinesterase activity was significantly decreased by 18.3, 25.2, and 21.7% in the 0.25, 1.0, and 4.0 mu g L-1 treatments, respectively. The expression of TCTP, GST3, Hsp70, Hsp27 mRNA were all up-regulated in juveniles with a dose-dependent manner exposed to MeHg. These results suggest that large yellow croaker juveniles have the potential to regulate the levels of antioxidant enzymes and initiate immune response in order to protect fish to some extent from oxidative stress induced by MeHg. |
| 关键词 | large yellow croaker juvenile MeHg exposure antioxidant defense system mRNA expression |
| DOI | 10.3389/fphys.2018.01436 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Marine Public Welfare Research Project of China[201405007]###975; National Natural Science Foundation of China[41306112]###976; National Natural Science Foundation of China[41406167]###977; National Natural Science Foundation of China[21307019]###978; China-APEC Cooperation Fund[2029901]###979; Science and Technology Support Program of China[2015BAD08B01]###980; Basic Scientific Research of SIO, China[JG1717]###981; Basic Scientific Research of SIO, China[JG1526]###982; National Marine Public Welfare Research Project of China[201405007]; National Natural Science Foundation of China[41306112]; National Natural Science Foundation of China[41406167]; National Natural Science Foundation of China[21307019]; China-APEC Cooperation Fund[2029901]; Science and Technology Support Program of China[2015BAD08B01]; Basic Scientific Research of SIO, China[JG1717]; Basic Scientific Research of SIO, China[JG1526] |
| WOS研究方向 | Physiology |
| WOS类目 | Physiology |
| WOS记录号 | WOS:000446897000001 |
| 出版者 | FRONTIERS MEDIA SA |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/160396 |
| 专题 | 中国科学院海洋研究所 |
| 通讯作者 | Huang, Wei |
| 作者单位 | 1.State Ocean Adm, Inst Oceanog 2, Key Lab Marine Ecosyst & Biogeochem, Hangzhou, Zhejiang, Peoples R China 2.Zhejiang Univ, Ocean Coll, Hangzhou, Zhejiang, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China 4.Zhejiang Surveying Inst Estuary & Coast, Hangzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Fangzhu,Huang, Wei,Liu, Qiang,et al. Responses of Antioxidant Defense and Immune Gene Expression in Early Life Stages of Large Yellow Croaker (Pseudosciaena crocea) Under Methyl Mercury Exposure[J]. FRONTIERS IN PHYSIOLOGY,2018,9:10. |
| APA | Wu, Fangzhu.,Huang, Wei.,Liu, Qiang.,Xu, Xiaoqun.,Zeng, Jiangning.,...&Jia, Shenghua.(2018).Responses of Antioxidant Defense and Immune Gene Expression in Early Life Stages of Large Yellow Croaker (Pseudosciaena crocea) Under Methyl Mercury Exposure.FRONTIERS IN PHYSIOLOGY,9,10. |
| MLA | Wu, Fangzhu,et al."Responses of Antioxidant Defense and Immune Gene Expression in Early Life Stages of Large Yellow Croaker (Pseudosciaena crocea) Under Methyl Mercury Exposure".FRONTIERS IN PHYSIOLOGY 9(2018):10. |
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| Responses of Antioxi（1340KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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