T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes

doi:10.1021/np8006843

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	T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes
	Ding, Ling 1,2,3; Pfoh, Roland 4; Ruehl, Stephan 4; Qin, Song 2; Laatsch, Hartmut 1; Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
	2009
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	72 期号:1 页码:99-101
文章类型	Article
摘要	Two new sesquiterpenes, 15-hydroxy-T-muurolol (3d) and 11,15-dihydroxy-T-muurolol (3e), along with the plant cadinenes T-muurolol (3f) and 3 alpha-hydroxy-T-muurolol (3g), were isolated from the marine-derived Streptomyces sp. M491. Their absolute configuration was established via NMR spectroscopy and X-ray crystallography of 3-oxo-T-muurolol (3a), which was reisolated from this strain. In addition, the absolute configuration of further sesquiterpenes previously reported from this strain was revised. These products were tested for their cytotoxicity against 37 human tumor cell lines using the MTT method. Only 3d was cytotoxic against a range of human tumor cell lines with a mean IC(50) of 6.7 mu g/mL.; Two new sesquiterpenes, 15-hydroxy-T-muurolol (3d) and 11,15-dihydroxy-T-muurolol (3e), along with the plant cadinenes T-muurolol (3f) and 3 alpha-hydroxy-T-muurolol (3g), were isolated from the marine-derived Streptomyces sp. M491. Their absolute configuration was established via NMR spectroscopy and X-ray crystallography of 3-oxo-T-muurolol (3a), which was reisolated from this strain. In addition, the absolute configuration of further sesquiterpenes previously reported from this strain was revised. These products were tested for their cytotoxicity against 37 human tumor cell lines using the MTT method. Only 3d was cytotoxic against a range of human tumor cell lines with a mean IC50 of 6.7 mu g/mL.
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np8006843
URL	查看原文
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000262761700018
引用统计	被引频次：53[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/1593
专题	实验海洋生物学重点实验室
通讯作者	Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
作者单位	1.Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Univ Gottingen, Dept Inorgan Chem, D-37077 Gottingen, Germany
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Ding, Ling,Pfoh, Roland,Ruehl, Stephan,et al. T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(1):99-101.
APA	Ding, Ling,Pfoh, Roland,Ruehl, Stephan,Qin, Song,Laatsch, Hartmut,&Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany.(2009).T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes.JOURNAL OF NATURAL PRODUCTS,72(1),99-101.
MLA	Ding, Ling,et al."T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes".JOURNAL OF NATURAL PRODUCTS 72.1(2009):99-101.

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