| Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus |
| Li, Ning1,2,3,4; Wang, Li-Jun1,2,4; Jiang, Bo1,2,4; Li, Xiang-qian1,2,4; Guo, Chuan-long1,2,3,4; Guo, Shu-ju1,2,4; Shi, Da-Yong1,2,3,4
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| 2018-05-10
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| 发表期刊 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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| ISSN | 0223-5234
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| 卷号 | 151页码:145-157 |
| 通讯作者 | Shi, Da-Yong([email protected])
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| 摘要 | Diabetes is a fast growing chronic metabolic disorder around the world. Dipeptidyl peptidase-4 (DPP-4) is a new promising target during type 2 diabetes glycemic control. Thus, a number of potent DPP-4 inhibitors were developed and play a rapidly evolving role in the management of type 2 diabetes in recent years. This article reviews the development of synthetic and natural DPP-4 inhibitors from 2012 to 2017 and provides their physico-chemical properties, biological activities against DPP-4 and selectivity over dipeptidyl peptidase-8/9. Moreover, the glucose-lowering mechanisms and the active site of DPP-4 are also discussed. We also discuss strategies and structure-activity relationships for identifying potent DPP-4 inhibitors, which will provide useful information for developing potent DPP-4 drugs as type 2 diabtes treatments. (C) 2018 Elsevier Masson SAS. All rights reserved. |
| 关键词 | DPP-4
Inhibitors
Analogs
Physico-chemical properties
SARs
Type 2 diabetes
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| DOI | 10.1016/j.ejmech.2018.03.041
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| 收录类别 | SCI
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| 语种 | 英语
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| 资助项目 | National Natural Science Foundation of China[81773586]###283; National Natural Science Foundation of China[81703354]###282; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]###556; Key research and development project of Shandong province[2016GSF201193]###551; Key research and development project of Shandong province[2016ZDJS07A13]###285; Key research and development project of Shandong province[2016GSF115002]###552; Key research and development project of Shandong province[2016GSF115009]###553; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014]###580; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Program of Chinese Academy of Sciences[ZSTH-026]###555; National Science Foundation of China (NSFC)-Shandong Joint Fund[U1706213]###1858; National Program for Support of Top-notch Young Professionals###557; Taishan scholar Youth Project of Shandong province and Qingdao Marine Biomedical Science and Technology Innovation Center project[2017-CXZ01-1-1]###1917; Taishan scholar Youth Project of Shandong province and Qingdao Marine Biomedical Science and Technology Innovation Center project[2017-CXZX01-3-9]###1860; National Natural Science Foundation of China[81773586]; National Natural Science Foundation of China[81703354]; Shandong Provincial Natural Science Foundation for Distinguished Young Scholars[JQ201722]; Key research and development project of Shandong province[2016GSF201193]; Key research and development project of Shandong province[2016ZDJS07A13]; Key research and development project of Shandong province[2016GSF115002]; Key research and development project of Shandong province[2016GSF115009]; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-DQC014]; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Program of Chinese Academy of Sciences[ZSTH-026]; National Science Foundation of China (NSFC)-Shandong Joint Fund[U1706213]; National Program for Support of Top-notch Young Professionals; Taishan scholar Youth Project of Shandong province and Qingdao Marine Biomedical Science and Technology Innovation Center project[2017-CXZ01-1-1]; Taishan scholar Youth Project of Shandong province and Qingdao Marine Biomedical Science and Technology Innovation Center project[2017-CXZX01-3-9] |
| WOS研究方向 | Pharmacology & Pharmacy
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| WOS类目 | Chemistry, Medicinal
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| WOS记录号 | WOS:000432640900011
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| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/159351
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| 专题 | 实验海洋生物学重点实验室
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| 通讯作者 | Shi, Da-Yong |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Beijing, Peoples R China
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| 第一作者单位 | 中国科学院海洋研究所
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| 通讯作者单位 | 中国科学院海洋研究所
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推荐引用方式
GB/T 7714 |
Li, Ning,Wang, Li-Jun,Jiang, Bo,et al. Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018,151:145-157.
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| APA |
Li, Ning.,Wang, Li-Jun.,Jiang, Bo.,Li, Xiang-qian.,Guo, Chuan-long.,...&Shi, Da-Yong.(2018).Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,151,145-157.
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| MLA |
Li, Ning,et al."Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 151(2018):145-157.
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