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| The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity | |
Liu, Huaide1; Wang, Jing2,3,4 ; Zhang, Quanbin2,3; Zhang, Hong2,3
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| 2018-07-01 | |
| 发表期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| ISSN | 0141-8130 |
| 卷号 | 113页码:82-89 |
| 通讯作者 | Wang, Jing([email protected]) |
| 摘要 | Ten fucoidan (FPS) derivatives were successfully synthesized, and their potential neuroprotective and anticomplement activities were investigated employing various established in vitro systems. The aim of the present study was to investigate the effects of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activities. All FPS derivatives possessed considerable neuroprotective and anticomplement activities and had stronger activities than FPS in certain tests. The in vitro results found that sulfated and benzoylated derivatives could reverse the decreased mitochondrial activity and decreased lactate dehydrogenase (LDH) and reactive oxygen species (ROS) release induced by 6-hydroxydopamine (6-OHDA, P < 0.01 or P < 0.001), which provides further evidence that sulfate and benzoylate groups could enhance the neuroprotective activity of fucoidan. In anticomplement experiments, all samples showed anticomplement activity in both systems; however, the sulfated and benzoylated derivatives showed better activity than fucoidan, with higher molecular weights showing the strongest activity. Available data suggested that substituted groups of fucoidan played an important role on neuroprotective and anticomplement activities. The mechanism of the influence of the neuroprotective and anticomplement activities of samples of the substituted groups was indicated. (C) 2018 Published by Elsevier B.V. |
| 关键词 | Fucoidan derivatives Molecular weights Substitute group Neuroprotective Anticomplement |
| DOI | 10.1016/j.ijbiomac.2018.02.109 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Fujian the Science and Technology Project of Fujian Province[2017T3015]###1902; Science and Technology Project of Shandong Province[2016GSF115031]###1875; Open Fund Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology[0F2015N007]###1903; Youth Innovation Promotion Association of CAS[2016190]###1423; Natural Science Foundation of China (NSFC)[41406144]###1904; Natural Science Foundation of the Jiangsu Higher Education Institutions of China[15KJB170016]###1905; Fujian the Science and Technology Project of Fujian Province[2017T3015]; Science and Technology Project of Shandong Province[2016GSF115031]; Open Fund Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology[0F2015N007]; Youth Innovation Promotion Association of CAS[2016190]; Natural Science Foundation of China (NSFC)[41406144]; Natural Science Foundation of the Jiangsu Higher Education Institutions of China[15KJB170016] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
| WOS记录号 | WOS:000432503100011 |
| 出版者 | ELSEVIER SCIENCE BV |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/159246 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Jing |
| 作者单位 | 1.Nantong Univ, Sch Ocean, Sch Life Sci, Nantong, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Nantong Branch, Nantong, Jiangsu, Peoples R China |
| 通讯作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Huaide,Wang, Jing,Zhang, Quanbin,et al. The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,113:82-89. |
| APA | Liu, Huaide,Wang, Jing,Zhang, Quanbin,&Zhang, Hong.(2018).The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,113,82-89. |
| MLA | Liu, Huaide,et al."The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 113(2018):82-89. |
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