Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection

doi:10.1016/j.fsi.2018.03.023

IOCAS-IR > 实验海洋生物学重点实验室

	Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection
	Li, Xue-peng1,2 ; Chi, Heng 1,2; Zhang, Jian 1,2
	2018-06-01
发表期刊	FISH & SHELLFISH IMMUNOLOGY
ISSN	1050-4648
卷号	77 页码:8-12
通讯作者	Zhang, Jian([email protected])
摘要	In mammals, beclin-1 is a key player that regulates autophagic activity. In fish, the immune function of beclin-1 is essentially unknown. In this study, we analyzed the involvement of tongue sole (Cynoglossus semilaevis) beclin-1 (named CsBECN1) in antibacterial immunity. CsBECN1 is composed of 451 amino acid residues and shares 84.5-95.1% overall sequence identities with other teleost beclin-1. CsBECN1 possesses a typical Bcl-2 homology domain 3 and an Atg6 domain. Expression of CsBECN1 occurred in multiple tissues and was upregulated during bacterial infection. Knockdown of CsBECN1 significantly enhanced bacterial dissemination in the tissues of tongue sole, whereas overexpression of CsBECN1 significantly reduced bacterial dissemination. Taken together, these results indicate that CsBECN1 is required for the antibacterial immunity of tongue sole.
关键词	Beclin-1 Cynoglossus semilaevis Gene expression Immune defense
DOI	10.1016/j.fsi.2018.03.023
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31330081]###1287; National Natural Science Foundation of China[31502197]###518; Key Laboratory of Mariculture (KLM), Ministry of Education, Ocean University of China###1880; Taishan Scholar Program of Shandong Province###423; National Natural Science Foundation of China[31330081]; National Natural Science Foundation of China[31502197]; Key Laboratory of Mariculture (KLM), Ministry of Education, Ocean University of China; Taishan Scholar Program of Shandong Province
WOS研究方向	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS类目	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
WOS记录号	WOS:000432644300002
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/159212
专题	实验海洋生物学重点实验室
通讯作者	Zhang, Jian
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Li, Xue-peng,Chi, Heng,Zhang, Jian. Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection[J]. FISH & SHELLFISH IMMUNOLOGY,2018,77:8-12.
APA	Li, Xue-peng,Chi, Heng,&Zhang, Jian.(2018).Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection.FISH & SHELLFISH IMMUNOLOGY,77,8-12.
MLA	Li, Xue-peng,et al."Beclin-1 is involved in tongue sole Cynoglossus semilaevis immune defense against bacterial infection".FISH & SHELLFISH IMMUNOLOGY 77(2018):8-12.

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