Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Analysis of the expression of metabolism-related genes and histopathology of the hepatopancreas of white shrimp Litopenaeus vannamei fed with aflatoxin B1 | |
Zhao, Wei1,2; Wang, Mengqiang1,2 ; Wang, Lei1,2; Liu, Mei1,2; Jiang, Keyong1,2; Xia, Sudong3; Qi, Cancan1,2; Wang, Baojie1,2
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| 2018-02-02 | |
| 发表期刊 | AQUACULTURE
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| ISSN | 0044-8486 |
| 卷号 | 485页码:191-196 |
| 通讯作者 | Wang, Baojie([email protected]) |
| 摘要 | Aflatoxins are produced in aquaculture feed by the fungi Aspergillus flavus or Aspergillus parasiticus. Aflatoxins can cause severe health problems in shrimp, and thus reduce the yield and profitability of shrimp cultures. We sought to understand the interaction between shrimp metabolism and aflatoxin B1 (AFB1) by analyzing the expression of Litopenaeus vannamei genes related to metabolism, and by analyzing histological alterations of the hepatopancreas, after shrimp were fed with AFB1. After being exposed to 15 ppm AFB1 for 12 d, shrimp exhibited increased mortality and severe histological damage to the hepatopancreas. Metabolism-related genes whose expression is affected by AFB1 are involved in metabolic functions, including the metabolism of pyrimidine, purine, mannose, arginine, proline, glycine, serine, galactose, sphingolipids, valine, leucine and isoleucine, and fatty acids. Our data contribute to our current understanding of how to control AFB1 toxicity through metabolic regulation. |
| 关键词 | Litopenaeus vannamei Hepatopancreas Aflatoxin B1 Metabolism Histopathology |
| DOI | 10.1016/j.aquaculture.2017.11.044 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Science and Technology Major Project of Shandong Province[2015ZDZX05002]###1277; STS key deployment project of Chinese Academy of Sciences[KFZD-SW-106]###1278; National Natural Science Foundation of China[41506192]###1279; Science and Technology Major Project of Shandong Province[2015ZDZX05002]; STS key deployment project of Chinese Academy of Sciences[KFZD-SW-106]; National Natural Science Foundation of China[41506192] |
| WOS研究方向 | Fisheries ; Marine & Freshwater Biology |
| WOS类目 | Fisheries ; Marine & Freshwater Biology |
| WOS记录号 | WOS:000417627900026 |
| 出版者 | ELSEVIER SCIENCE BV |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/157757 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Baojie |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 3.Tianjin Fisheries Res Inst, Tianjin 300221, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 通讯作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Zhao, Wei,Wang, Mengqiang,Wang, Lei,et al. Analysis of the expression of metabolism-related genes and histopathology of the hepatopancreas of white shrimp Litopenaeus vannamei fed with aflatoxin B1[J]. AQUACULTURE,2018,485:191-196. |
| APA | Zhao, Wei.,Wang, Mengqiang.,Wang, Lei.,Liu, Mei.,Jiang, Keyong.,...&Wang, Baojie.(2018).Analysis of the expression of metabolism-related genes and histopathology of the hepatopancreas of white shrimp Litopenaeus vannamei fed with aflatoxin B1.AQUACULTURE,485,191-196. |
| MLA | Zhao, Wei,et al."Analysis of the expression of metabolism-related genes and histopathology of the hepatopancreas of white shrimp Litopenaeus vannamei fed with aflatoxin B1".AQUACULTURE 485(2018):191-196. |
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