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	Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers
	Sun, Lina1; Lin, Chenggang1; Li, Xiaoni1; Xing, Lili1; Huo, Da1; Sun, Jingchun1; Zhang, Libin1; Yang, Hongsheng1
	2018-07-03
发表期刊	FRONTIERS IN PHYSIOLOGY
ISSN	1664-042X
卷号	9
文章类型	Article
摘要	Sea cucumbers exposed to stressful circumstances eviscerate most internal organs, and then regenerate them rapidly under favorable environments. Reversible protein phosphorylation and acetylation are major modifications regulating protein function. Herein, for the first time, we perform quantitative phospho- and acetyl proteomics analyses of intestine regeneration in a sea cucumber species Apostichopus japonicus. We identified 1,862 phosphorylation sites in 1,169 proteins, and 712 acetylation sites in 470 proteins. Of the 147 and 251 proteins differentially modified by phosphorylation and acetylation, respectively, most were related to cytoskeleton biogenesis, protein synthesis and modification, signal recognition and transduction, energy production and conversion, or substance transport and metabolism. Phosphorylation appears to play a more important role in signal recognition and transduction than acetylation, while acetylation is of greater importance in posttranslational modification, protein turnover, chaperones; energy production and conversion; amino acid and lipid transport and metabolism. These results expanded our understanding of the regulatory mechanisms of posttranslational modifications in intestine regeneration of sea cucumbers after evisceration.
关键词	sea cucumber intestine regeneration phosphoproteomics acetyl proteomics posttranslational modification
学科领域	Physiology
DOI	10.3389/fphys.2018.00836
收录类别	SCIE
语种	英语
WOS研究方向	Physiology
WOS记录号	WOS:000437211600002
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：9[WOS]   [WOS记录]     [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/157552
专题	海洋生态与环境科学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Sun, Lina,Lin, Chenggang,Li, Xiaoni,et al. Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers[J]. FRONTIERS IN PHYSIOLOGY,2018,9.
APA	Sun, Lina.,Lin, Chenggang.,Li, Xiaoni.,Xing, Lili.,Huo, Da.,...&Yang, Hongsheng.(2018).Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers.FRONTIERS IN PHYSIOLOGY,9.
MLA	Sun, Lina,et al."Comparative Phospho- and Acetyl Proteomics Analysis of Posttranslational Modifications Regulating Intestine Regeneration in Sea Cucumbers".FRONTIERS IN PHYSIOLOGY 9(2018).

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Comparative Phospho-（4566KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览

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