Antimicrobial alkaloids produced by the mangrove endophyte Penicillium brocae MA-231 using the OSMAC approach

doi:10.1039/c7ra12081h

IOCAS-IR > 实验海洋生物学重点实验室

	Antimicrobial alkaloids produced by the mangrove endophyte Penicillium brocae MA-231 using the OSMAC approach
	Meng, Ling-Hong; Li, Xiao-Ming; Liu, Yang; Xu, Gang-Ming; Wang, Bin-Gui
	2017
发表期刊	RSC ADVANCES
ISSN	2046-2069
卷号	7 期号:87 页码:55026-55033
通讯作者	Wang, Bin-Gui([email protected])
摘要	The OSMAC (one strain-many compounds) protocol was used in this study to obtain various metabolites from the mangrove-derived endophytic fungus Penicillium brocae MA-231. As a result, four new thiodiketopiperazine alkaloids, penicibrocazines F-I (1-4), together with two new N-containing p-hydroxyphenopyrrozin derivatives brocapyrrozins A and B (7 and 8) as well as six known alkaloids (5, 6, and 9-12), were identified from the extract of the Czapek culture medium of the fungus. Their structures and absolute configurations were determined through interpretation of their spectroscopic data and by X-ray crystallographic analysis. Compounds 7 and 9 exhibited potent activity against human pathogenic bacterium Staphylococcus aureus with MIC values of 0.125 and 0.5 mg mL(-1), respectively.
DOI	10.1039/c7ra12081h
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of China[81673351]###1262; Natural Science Foundation of China[31600267]###1263; Key Laboratory of Marine Bioactive Substance and Modern Analytical Technique, SOA[MBSMAT-2015-05]###1264; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017250]###1265; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2016M590667]###1266; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017T100521]###1267; China Postdoctoral Science Foundation[2016M590667]###1268; China Postdoctoral Science Foundation[2017T100521]###1269; Taishan Scholar Project from Shandong Province###1179; Natural Science Foundation of China[81673351]###1262; Natural Science Foundation of China[31600267]###1263; Key Laboratory of Marine Bioactive Substance and Modern Analytical Technique, SOA[MBSMAT-2015-05]###1264; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017250]###1265; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2016M590667]###1266; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017T100521]###1267; China Postdoctoral Science Foundation[2016M590667]###1268; China Postdoctoral Science Foundation[2017T100521]###1269; Taishan Scholar Project from Shandong Province###1179; Natural Science Foundation of China[81673351]; Natural Science Foundation of China[31600267]; Key Laboratory of Marine Bioactive Substance and Modern Analytical Technique, SOA[MBSMAT-2015-05]; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017250]; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2016M590667]; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2017T100521]; China Postdoctoral Science Foundation[2016M590667]; China Postdoctoral Science Foundation[2017T100521]; Taishan Scholar project from Shandong province
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000418378100014
出版者	ROYAL SOC CHEMISTRY
引用统计	被引频次：35[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/157392
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui
作者单位	Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Key Lab Expt Marine Biol,Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Meng, Ling-Hong,Li, Xiao-Ming,Liu, Yang,et al. Antimicrobial alkaloids produced by the mangrove endophyte Penicillium brocae MA-231 using the OSMAC approach[J]. RSC ADVANCES,2017,7(87):55026-55033.
APA	Meng, Ling-Hong,Li, Xiao-Ming,Liu, Yang,Xu, Gang-Ming,&Wang, Bin-Gui.(2017).Antimicrobial alkaloids produced by the mangrove endophyte Penicillium brocae MA-231 using the OSMAC approach.RSC ADVANCES,7(87),55026-55033.
MLA	Meng, Ling-Hong,et al."Antimicrobial alkaloids produced by the mangrove endophyte Penicillium brocae MA-231 using the OSMAC approach".RSC ADVANCES 7.87(2017):55026-55033.