The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity

doi:10.1016/j.ijbiomac.2017.07.089

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	The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity
	Jin, Weihua 1,2; Zhang, Wenjing1,3 ; Liu, Ge 1; Yao, Jianting 1; Shan, Tifeng 1; Sun, Chaomin 1,4; Zhang, Quanbin 1,4
	2017-12-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	105 页码:686-692
通讯作者	Sun, Chaomin([email protected]) ; Zhang, Quanbin([email protected])
摘要	Polysaccharides derived from Sargassum thunbergii were prepared to investigate the structure-activity relationship between polysaccharides and anti-tumor activity in vitro. Many factors were examined. Overall, STW (polysaccharide extracted by hot water) had the best activity, followed by STJ (polysaccharide extracted by dilute alkali), and then STA (polysaccharide extracted by dilute acid). Location of algae had no effect at 500 mu g/mL and 1000 mu g/mL, while STW-QD (algae collected from Qingdao, China) had the best activity, followed by STW-WZ (algae collected from Wenzhou, China) and STW-LJ (algae collected from Lianjiang, China) and then STW-DL (algae collected from Dalian, China) and STW-RC (algae collected from Rongcheng, China) at 250 mu g/mL. Moreover, molecular weight had no effect at 1000 mu g/mL, while higher molecular weights were associated with better activities at 250 mu g/mL and 500 mu g/mL. Sulfate content had no effect at 1000 mu g/mL, while anti-tumor activities decreased accompanying with the changes of sulfate content. Uronic acid content was an important factor influencing activity. The fractions of STW showed little anti-tumor activity; however, the mixture of the fractions of STW showed approximately 60% inhibition. Overall, these findings suggested that the anti-tumor activity of polysaccharides required multilateral cooperation and that some of the effective components were lost. (C) 2017 Elsevier B.V. All rights reserved.
关键词	Heteropolysaccharide Anti-tumor activity Sargassum thunbergii Structure-activity relationship
DOI	10.1016/j.ijbiomac.2017.07.089
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[41506165]###1189; Shandong Provincial Natural Science Foundation, China[ZR2014DQ024]###1190; Science and Technology program of applied basic research projects of Qingdao Municipal[15-9-1-74-jch]###1191; Ocean Public Welfare Scientific Research Project###1192; State Oceanic Administration of the People's Republic of China[201405040]###1193; National Natural Science Foundation of China[41506165]; Shandong Provincial Natural Science Foundation, China[ZR2014DQ024]; Science and Technology program of applied basic research projects of Qingdao Municipal[15-9-1-74-jch]; Ocean Public Welfare Scientific Research Project; State Oceanic Administration of the People's Republic of China[201405040]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:000414882900077
出版者	ELSEVIER SCIENCE BV
引用统计	被引频次：55[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/157279
专题	实验海洋生物学重点实验室
通讯作者	Sun, Chaomin; Zhang, Quanbin
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310014, Zhejiang, Peoples R China 3.Zhejiang Univ, Sch Basic Med Sci, Hangzhou 310058, Zhejiang, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
第一作者单位	实验海洋生物学重点实验室
通讯作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Jin, Weihua,Zhang, Wenjing,Liu, Ge,et al. The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,105:686-692.
APA	Jin, Weihua.,Zhang, Wenjing.,Liu, Ge.,Yao, Jianting.,Shan, Tifeng.,...&Zhang, Quanbin.(2017).The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,105,686-692.
MLA	Jin, Weihua,et al."The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 105(2017):686-692.