Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai

doi:10.3390/md14120223

IOCAS-IR > 实验海洋生物学重点实验室

	Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai
	Li, Hong-Lei1,2 ; Li, Xiao-Ming 1; Liu, Hui1,2 ; Meng, Ling-Hong1 ; Wang, Bin-Gui1
	2016-12-01
发表期刊	MARINE DRUGS
ISSN	1660-3397
卷号	14 期号:12 页码:8
通讯作者	Meng, Ling-Hong([email protected]) ; Wang, Bin-Gui([email protected])
摘要	Two new diphenylketones (1 and 2), a new xanthone (3), and a known xanthone analogue (4) were isolated and identified from Talaromyces islandicus EN-501, an endophytic fungus obtained from the fresh collected marine red alga Laurencia okamurai. Their structures were elucidated on the basis of NMR spectroscopic and X-ray crystallographic analysis. The joint isolation of benzophenones and xanthones from the same fungal strain supports the biogenesis of xanthones via a benzophenone intermediate. It is worth mentioning that xanthones 3 and 4 have a methyl group at C-6 and C-2, respectively, which is uncommon compared with typical xanthones usually having a methyl group at C-8. Compounds 1-4 exhibited potent antioxidative activities against DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2-azino-bis(3-ethylbenzothiazoline-6-sulphonate) radicals with IC50 values ranging from 0.58 to 6.92 g/mL, which are stronger than that of the positive controls BHT (butylated hydroxytoluene) and ascorbic acid. Compounds 1, 3, and 4 also showed inhibitory activities against several pathogenic bacteria.
关键词	Laurencia okamurai Talaromyces islandicus diphenylketone xanthone antioxidative activity antibacterial activity
DOI	10.3390/md14120223
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31330009]###1177; Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02]###1178; Taishan Scholar Project from Shandong Province###1179; National Natural Science Foundation of China[31330009]; Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02]; Taishan Scholar Project from Shandong Province
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal
WOS记录号	WOS:000392486100007
出版者	MDPI AG
引用统计	被引频次：31[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/157264
专题	实验海洋生物学重点实验室
通讯作者	Meng, Ling-Hong; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Key Lab Expt Marine Biol,Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Li, Hong-Lei,Li, Xiao-Ming,Liu, Hui,et al. Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai[J]. MARINE DRUGS,2016,14(12):8.
APA	Li, Hong-Lei,Li, Xiao-Ming,Liu, Hui,Meng, Ling-Hong,&Wang, Bin-Gui.(2016).Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai.MARINE DRUGS,14(12),8.
MLA	Li, Hong-Lei,et al."Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai".MARINE DRUGS 14.12(2016):8.