Vascular targeted chitosan-derived nanoparticles as docetaxel carriers for gastric cancer therapy

doi:10.1016/j.ijbiomac.2018.12.262

IOCAS-IR > 实验海洋生物学重点实验室

	Vascular targeted chitosan-derived nanoparticles as docetaxel carriers for gastric cancer therapy
	Zhang, Enhui1,2,3 ; Xing, Ronge1,2,3 ; Liu, Song 1,2,3; Li, Kecheng 1,2,3; Qin, Yukun1,2,3 ; Yu, Huahua1,2,3 ; Li, Pengcheng1,2,3
	2019-04-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	126 页码:662-672
通讯作者	Xing, Ronge([email protected]) ; Li, Pengcheng([email protected])
摘要	A gastric cancer angiogenesis marker peptide, GX1, is promising to be a desirable ligand for anti-angiogenesis targeted drug of gastric cancer treatment. In this study, GX1 was utilized to fabricate a multifunctional vascular targeting docetaxel (DCT)-loaded nanoparticle with N-deoxycholic acid glycol chitosan (DGC) as the carrier and GX1-PEG-deoxycholic acid (GPD) conjugate as the targeting ligand. The mean size of obtained GX1-DGC-DCT was 150.9 nm with a narrow size distribution and their shape was spherical with smooth surface texture. The in vitro drug release test revealed a sustained release manner and an acid pH could accelerate the release compared with the neutral pH. Furthermore, GX1-DGC-DCT showed stronger cytotoxicity against co-cultured gastric cancer cells and human umbilical vein endothelial cells (co-HUVEC) than DCT within 100 mu M. In addition, GX1 efficiently enhanced the cellular uptake of nanoparticles in co-HUVEC cells as confirmed by confocal fluorescence scanning microscopy. Moreover, in vivo delivery of GX1-DGC-DCT was demonstrated to inhibit tumor growth in SGC791 tumor-bearing mice with tumor inhibition rate (TIR) of 67.05% and no weight loss of mice was observed. The anti-tumor effects were further confirmed by H&E and TUNEL analysis. Therefore, this new drug delivery system represents a potential strategy for gastric cancer therapy. (C) 2019 Elsevier B.V. All rights reserved.
关键词	Targeted drug delivery Chitosan Docetaxel
DOI	10.1016/j.ijbiomac.2018.12.262
收录类别	SCI
语种	英语
资助项目	Special projects of Foshan science and technology innovation team[2017IT100054]###204; National Key R&D Program of China[2018YFC0311305]###203; National Key R&D Program of China[2018YFC0311305]; Special projects of Foshan science and technology innovation team[2017IT100054]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:000460710000076
出版者	ELSEVIER SCIENCE BV
引用统计	被引频次：36[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/155298
专题	实验海洋生物学重点实验室
通讯作者	Xing, Ronge; Li, Pengcheng
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Zhang, Enhui,Xing, Ronge,Liu, Song,et al. Vascular targeted chitosan-derived nanoparticles as docetaxel carriers for gastric cancer therapy[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2019,126:662-672.
APA	Zhang, Enhui.,Xing, Ronge.,Liu, Song.,Li, Kecheng.,Qin, Yukun.,...&Li, Pengcheng.(2019).Vascular targeted chitosan-derived nanoparticles as docetaxel carriers for gastric cancer therapy.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,126,662-672.
MLA	Zhang, Enhui,et al."Vascular targeted chitosan-derived nanoparticles as docetaxel carriers for gastric cancer therapy".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 126(2019):662-672.

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