Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp | |
| Zhu, Guanghui1,2; Li, Shihao3,4,5; Wu, Jun2; Li, Fuhua3,4,5; Zhao, Xing-Ming1 | |
| 2019-03-11 | |
| 发表期刊 | FRONTIERS IN PHYSIOLOGY
 |
| ISSN | 1664-042X |
| 卷号 | 10页码:9 |
| 通讯作者 | Li, Fuhua([email protected]) ; Zhao, Xing-Ming([email protected]) |
| 摘要 | White spot syndrome virus (WSSV) is one of the major threats to shrimp aquaculture. It has been found that the signal transducer and activator of transcription (STAT) protein plays an important role in the antiviral immunity of shrimp with a WSSV infection. However, the mechanism that underlies the STAT-mediated antiviral responses in shrimp, against WSSV infection, remains unclear. In this work, based on the gene expression profiles of shrimp with an injection of WSSV and STAT double strand RNA (dsRNA), we constructed a gene co-expression network for shrimp and identified the gene modules that are possibly responsible for STAT-mediated antiviral responses. These gene modules are found enriched in the regulation of the viral process, JAK-STAT cascade and the regulation of immune effector process pathways. The gene modules identified here provide insights into the molecular mechanism that underlies the STAT-mediated antiviral response of shrimp, against WSSV. |
| 关键词 | antivirus response co-expression network gene module STAT dsRNA white spot syndrome virus shrimp |
| DOI | 10.3389/fphys.2019.00212 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Open Fund of Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China[OF2015NO13]###281; Natural Science Foundation of Shanghai[17ZR1445600]###280; National Natural Science Foundation of China[91530321]###279; National Natural Science Foundation of China[61572363]###278; National Natural Science Foundation of China[61772368]###277; National Natural Science Foundation of China[61772368]; National Natural Science Foundation of China[61572363]; National Natural Science Foundation of China[91530321]; Natural Science Foundation of Shanghai[17ZR1445600]; Open Fund of Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China[OF2015NO13] |
| WOS研究方向 | Physiology |
| WOS类目 | Physiology |
| WOS记录号 | WOS:000460860100001 |
| 出版者 | FRONTIERS MEDIA SA |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/155262 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Li, Fuhua; Zhao, Xing-Ming |
| 作者单位 | 1.Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China 2.Tongji Univ, Dept Comp Sci & Technol, Shanghai, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China |
| 通讯作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Zhu, Guanghui,Li, Shihao,Wu, Jun,et al. Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp[J]. FRONTIERS IN PHYSIOLOGY,2019,10:9. |
| APA | Zhu, Guanghui,Li, Shihao,Wu, Jun,Li, Fuhua,&Zhao, Xing-Ming.(2019).Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp.FRONTIERS IN PHYSIOLOGY,10,9. |
| MLA | Zhu, Guanghui,et al."Identification of Functional Gene Modules Associated With STAT-Mediated Antiviral Responses to White Spot Syndrome Virus in Shrimp".FRONTIERS IN PHYSIOLOGY 10(2019):9. |
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| Identification of Fu（2414KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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