BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes

doi:10.1016/j.ijbiomac.2017.08.042

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	BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes
	Xu, Qi 1,2,3; Luo, Jiao 1,2,3; Wu, Ning 1,3; Zhang, Renshuai 1,3; Shi, Dayong 1,2,3
	2018
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷号	106 页码:379-386
文章类型	Article
摘要	Insulin resistance is a key feature of type 2 diabetes mellitus (T2DM) and is characterized by defects in insulin signaling. Protein tyrosine phosphatase 1B (PTP1B) is a major negative regulator of insulin signaling cascade and has attracted intensive investigation in recent T2DM therapy study. BPN, a marine derived bromophenol compound, was isolated from the red alga Rhodomela confervoides. This study investigated the effects of BPN on the insulin signaling pathway in insulin-resistant C2C12 myotubes by inhibiting PTP1B. Molecular docking study and analysis of small-molecule interaction with PTP1B all showed BPN inhibited PTP1B activity via binding to the catalytic site through hydrogen bonds. We then found that BPN permeated into C2C12 myotubes, on the one hand, activated insulin signaling in an insulin independent manner in C2C12 cells; on the other hand, ameliorated palmitate-induced insulin resistance through augmenting insulin sensitivity. Moreover, our studies also showed that FTP1B inhibition by BPN increased glucose uptake in normal and insulin-resistant C2C12 myotubes through glucose transporter 4 (GLUT4) translocation. Taken together, BPN activates insulin signaling and alleviates insulin resistance and represents a potential candidate for further development as an antidiabetic agent. (C) 2017 Elsevier B.V. All rights reserved.
关键词	Bpn Protein Tyrosine Phosphatase 1b Insulin Signaling Insulin Resistance C2c12 Myotubes
DOI	10.1016/j.ijbiomac.2017.08.042
收录类别	SCI
语种	英语
WOS记录号	WOS:000417661600043
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/154321
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Xu, Qi,Luo, Jiao,Wu, Ning,et al. BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,106:379-386.
APA	Xu, Qi,Luo, Jiao,Wu, Ning,Zhang, Renshuai,&Shi, Dayong.(2018).BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,106,379-386.
MLA	Xu, Qi,et al."BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 106(2018):379-386.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
a marine-derived PTP（1900KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览