Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis

doi:10.3390/ijms18091848

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	Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis
	Jiang, Shuai 1,2; Sun, Li 1,2
	2017-09-01
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号	18 期号:9
文章类型	Article
摘要	CD209 is an immune receptor that plays an important role in the initiation of innate immunity and activation of adaptive immunity in mammals. However, much less is known about the immunological function of CD209 in lower vertebrates. In the present study, we examined the immune effect of a CD209 homologue (CsCD209) from the teleost fish tongue sole Cynoglossus semilaevis. CsCD209 possesses a lectin domain that shares high levels of similarity with the lectin domains of human and mouse CD209. CsCD209 expression was most abundant in kidney and blood and was significantly upregulated during bacterial infection. CsCD209 exhibited a subcellular localization mainly on the cell surface of myelomonocytes. Recombinant CsCD209 displayed apparent binding capacities to a broad range of bacteria and fungi, and significantly promoted the phagocytosis of the bound bacteria by C. semilaevis leukocytes. Collectively, the results indicate that teleost CD209 serves as a pattern recognition receptor that exerts an influence on the phagocytosis process during pathogen infections.
关键词	Cd209 Lectin Cynoglossus Semilaevis Microbial Recognition Phagocytosis
DOI	10.3390/ijms18091848
收录类别	SCI
语种	英语
WOS记录号	WOS:000411963800027
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/143226
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
第一作者单位	实验海洋生物学重点实验室
推荐引用方式 GB/T 7714	Jiang, Shuai,Sun, Li. Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017,18(9).
APA	Jiang, Shuai,&Sun, Li.(2017).Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(9).
MLA	Jiang, Shuai,et al."Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18.9(2017).

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文件名称/大小	文献类型	版本类型	开放类型	使用许可
Tongue Sole CD209_ A（8563KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览