Two Prenyltransferases Govern a Consecutive Prenylation Cascade in the Biosynthesis of Echinulin and Neoechinulin

doi:10.1021/acs.orglett.7b02926

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	Two Prenyltransferases Govern a Consecutive Prenylation Cascade in the Biosynthesis of Echinulin and Neoechinulin
	Wohlgemuth, Viola 1; Kindinger, Florian 1; Xie, Xiulan 2; Wang, Bin-Gui3 ; Li, Shu-Ming 1
	2017-11-03
发表期刊	ORGANIC LETTERS
卷号	19 期号:21 页码:5928-5931
文章类型	Article
摘要	Two prenyltransferases from Aspergillus ruber control the echinulin biosynthesis via exceptional sequential prenylations. EchPT1 catalyzes the first prenylation step, leading to preechinulin. The unique EchPT2 attaches, in a consecutive prenylation cascade, up to three dimethylallyl moieties to preechinulin and its dehydro forms neoechinulins A and B, resulting in the formation of at least 23 2- to 4-fold prenylated derivatives. Confirming these products in fungal extracts unravels the unprecedented catalytic relevance of EchPT2 for structural diversity.
DOI	10.1021/acs.orglett.7b02926
收录类别	SCI
语种	英语
WOS记录号	WOS:000414723900055
引用统计	被引频次：28[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/143069
专题	实验海洋生物学重点实验室
作者单位	1.Philipps Univ Marburg, Inst Pharmazeut Biol & Biotechnol, Robert Koch Str 4, D-35037 Marburg, Germany 2.Philipps Univ Marburg, Fachbereich Chem, Hans Meerwein Str, D-35032 Marburg, Germany 3.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Wohlgemuth, Viola,Kindinger, Florian,Xie, Xiulan,et al. Two Prenyltransferases Govern a Consecutive Prenylation Cascade in the Biosynthesis of Echinulin and Neoechinulin[J]. ORGANIC LETTERS,2017,19(21):5928-5931.
APA	Wohlgemuth, Viola,Kindinger, Florian,Xie, Xiulan,Wang, Bin-Gui,&Li, Shu-Ming.(2017).Two Prenyltransferases Govern a Consecutive Prenylation Cascade in the Biosynthesis of Echinulin and Neoechinulin.ORGANIC LETTERS,19(21),5928-5931.
MLA	Wohlgemuth, Viola,et al."Two Prenyltransferases Govern a Consecutive Prenylation Cascade in the Biosynthesis of Echinulin and Neoechinulin".ORGANIC LETTERS 19.21(2017):5928-5931.

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