| Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload | |
| Jia, Yingli1,2; Sun, Yi1,2; Weng, Lin1,2; Li, Yingjie1,2; Zhang, Quanbin3; Zhou, Hong1,2; Yang, Baoxue1,2 | |
| 2016-08-22 | |
| 发表期刊 | SCIENTIFIC REPORTS
 |
| 卷号 | 6 |
| 文章类型 | Article |
| 摘要 | Albuminuria is a causative and aggravating factor for progressive renal damage in chronic kidney disease (CKD). The aim of this study was to determine if low molecular weight fucoidan (LMWF) could protect renal function and tubular cells from albumin overload caused injury. Treatment with 10 mg/g bovine serum albumin caused renal dysfunction, morphological changes, and overexpression of inflammation and fibrosis associated proteins in 129S2/Sv mice. LMWF (100 mg/kg) protected against kidney injury and renal dysfunction with decreased blood creatinine by 34% and urea nitrogen by 25%, increased creatinine clearance by 48%, and decreased significantly urinary albumin concentration. In vitro proximal tubule epithelial cell (NRK-52E) model showed that LMWF dose-dependently inhibited overexpression of proinflammatory and profibrotic factors, oxidative stress and apoptosis caused by albumin overload. These experimental results indicate that LMWF protects against albumin overload caused renal injury by inhibiting inflammation, fibrosis, oxidative stress and apoptosis, which suggests that LMWF could be a promising candidate drug for preventing CKD. |
| DOI | 10.1038/srep31759 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000381706900002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/135857 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Peking Univ, Minist Educ, State Key Lab Nat & Biomimet Drugs, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China 2.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Yingli,Sun, Yi,Weng, Lin,et al. Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Jia, Yingli.,Sun, Yi.,Weng, Lin.,Li, Yingjie.,Zhang, Quanbin.,...&Yang, Baoxue.(2016).Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload.SCIENTIFIC REPORTS,6. |
| MLA | Jia, Yingli,et al."Low molecular weight fucoidan protects renal tubular cells from injury induced by albumin overload".SCIENTIFIC REPORTS 6(2016). |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Low molecular weight（1889KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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