| Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides | |
Song, Lin1,2 ; Chen, Xiaolin1; Liu, Xiaodong3; Zhang, Fubo3; Hu, Linfeng1; Yue, Yang1,2; Li, Kecheng1; Li, Pengcheng1
| |
| 2016 | |
| 发表期刊 | MARINE DRUGS
 |
| 卷号 | 14期号:1 |
| 文章类型 | Article |
| 摘要 | Three marine macroalgae, i.e., Grateloupia filicina, Ulva pertusa and Sargassum qingdaoense, were selected as the deputies of Rhodophyta, Chlorophyta and Ochrophyta for comparative analysis of the molecular structures and biological activities of sulfated polysaccharides (SP). The ratio of water-soluble polysaccharides, the monosaccharide composition and the sulfated contents of three extracted SPs were determined, and their structures were characterized by Fourier transformation infrared spectroscopy. In addition, biological activity analysis showed that all three SPs had immune-modulatory activity both in vitro and in vivo, and SPs from S. qingdaoense had the best effect. Further bioassays showed that three SPs could not only enhance the immunity level stimulated by inactivated avian influenza virus (AIV) in vivo but also significantly inhibited the activity of activated AIV (H9N2 subtype) in vitro. G. filicina SP exhibited the strongest anti-AIV activity. These results revealed the variations in structural features and bioactivities among three SPs and indicated the potential adjuvants for immune-enhancement and anti-AIV. |
| 关键词 | Marine Macroalgae Sulfated Polysaccharides Structure Features Immune Enhancement Anti-aiv |
| DOI | 10.3390/md14010004 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000374586800004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/131080 |
| 专题 | 海洋生物技术研发中心 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Qingdao Agr Univ, Coll Anim Sci & Technol, 700 Changcheng Rd, Qingdao 266109, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Song, Lin,Chen, Xiaolin,Liu, Xiaodong,et al. Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides[J]. MARINE DRUGS,2016,14(1). |
| APA | Song, Lin.,Chen, Xiaolin.,Liu, Xiaodong.,Zhang, Fubo.,Hu, Linfeng.,...&Li, Pengcheng.(2016).Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides.MARINE DRUGS,14(1). |
| MLA | Song, Lin,et al."Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides".MARINE DRUGS 14.1(2016). |
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| Characterization and（2960KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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