Understanding the Heat Shock Response in the Sea Cucumber Apostichopus japonicus, Using iTRAQ-Based Proteomics

doi:10.3390/ijms17020150

	Understanding the Heat Shock Response in the Sea Cucumber Apostichopus japonicus, Using iTRAQ-Based Proteomics
	Xu, Dongxue1,2 ; Sun, Lina 1; Liu, Shilin 1; Zhang, Libin 1; Yang, Hongsheng1
	2016-02-01
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷号	17 期号:2
文章类型	Article
摘要	The sea cucumber Apostichopus japonicus is exploited as a commercial species owing to their high nutritive and medicinal value. Recent high summer temperatures have caused high mortality rates in A. japonicus. In this study, we applied the isobaric tag for relative and absolute quantitation (iTRAQ) technique to investigate the global protein expression profile under an acute short-term (48 h) heat stress. In total, 3432 proteins were identified, and 127 proteins showed significant heat stress responses, with 61 upregulated proteins and 66 downregulated proteins. Our results suggest that heat stress influenced the expression of proteins involved in various biological processes, such as tissue protection and detoxification, lipid and amino acid metabolism, energy production and usage, transcription and translation, cell apoptosis, and cell proliferation. These findings provide a better understanding about the response and thermo-tolerance mechanisms of A. japonicus under heat stress.
关键词	Apostichopus Japonicus Heat Stress Itraq Proteomics Analysis
DOI	10.3390/ijms17020150
收录类别	SCI
语种	英语
WOS记录号	WOS:000371830800089
引用统计	被引频次：47[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/126195
专题	海洋生态与环境科学重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xu, Dongxue,Sun, Lina,Liu, Shilin,et al. Understanding the Heat Shock Response in the Sea Cucumber Apostichopus japonicus, Using iTRAQ-Based Proteomics[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016,17(2).
APA	Xu, Dongxue,Sun, Lina,Liu, Shilin,Zhang, Libin,&Yang, Hongsheng.(2016).Understanding the Heat Shock Response in the Sea Cucumber Apostichopus japonicus, Using iTRAQ-Based Proteomics.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,17(2).
MLA	Xu, Dongxue,et al."Understanding the Heat Shock Response in the Sea Cucumber Apostichopus japonicus, Using iTRAQ-Based Proteomics".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17.2(2016).

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