Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma

doi:10.1007/s11010-012-1235-9

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	Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma
	Li Chunbao 1; Cheng Qianpeng 2; Liu Jia 3,4; Wang Bin5 ; Chen Dongfeng 5; Liu Yujie 1; Liu, YJ (reprint author), Gen Hosp Peoples Liberat Army, Dept Orthopaed Surg, Beijing 100853, Peoples R China.
	2012-05-01
发表期刊	MOLECULAR AND CELLULAR BIOCHEMISTRY
ISSN	0300-8177
卷号	364 期号:1-2 页码:337-344
文章类型	Article
摘要	Osteosarcoma (OS) severely threatens the health of young people and understanding on the molecular mechanisms of OS etiology enables gene therapy to become an effective therapeutic modality. However, insufficient expression level of genes using existing vectors limits the clinical application of gene therapy for OS. To solve the problem, we developed an oncolytic adenoviral vector, OAT, which can selectively and efficiently replicate in OS cells to enhance the expression of transferred genes. We demonstrated that OAT-mediated TRAIL expression is significantly elevated after infection of OS cells than replication-incompetent Ad5 vector. Increased antitumor capacity was observed in OS cells after OAT-TRAIL treatment both in vitro and in vivo. In normal cells, adenoviral replication, TRAIL expression and growth-inhibiting effect were quite limited when OAT-TRAIL was administrated, showing a high biosafety of this oncolytic adenoviral vector. Collectively, we generated an efficient and promising expression vector for OS gene therapy.
关键词	Gene Therapy Osteosarcoma Adenoviral Vector Trail Biological Therapy Oncolytic Adenovirus
学科领域	Cell Biology
DOI	10.1007/s11010-012-1235-9
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000303458300036
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/12370
专题	实验海洋生物学重点实验室
通讯作者	Liu, YJ (reprint author), Gen Hosp Peoples Liberat Army, Dept Orthopaed Surg, Beijing 100853, Peoples R China.
作者单位	1.Gen Hosp Peoples Liberat Army, Dept Orthopaed Surg, Beijing 100853, Peoples R China 2.Gen Hosp Beijing Mil Reg, Dept Endocrinol & Metab, Beijing 100700, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 5.Third Mil Med Univ, Daping Hosp, Gastroenterol Inst Surg Res, Chongqing 400042, Peoples R China
推荐引用方式 GB/T 7714	Li Chunbao,Cheng Qianpeng,Liu Jia,et al. Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2012,364(1-2):337-344.
APA	Li Chunbao.,Cheng Qianpeng.,Liu Jia.,Wang Bin.,Chen Dongfeng.,...&Liu, YJ .(2012).Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma.MOLECULAR AND CELLULAR BIOCHEMISTRY,364(1-2),337-344.
MLA	Li Chunbao,et al."Potent growth-inhibitory effect of TRAIL therapy mediated by double-regulated oncolytic adenovirus on osteosarcoma".MOLECULAR AND CELLULAR BIOCHEMISTRY 364.1-2(2012):337-344.

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